NCT01905865

Brief Summary

Background: \- Parents of a child with an undiagnosed medical condition face a lot of uncertainty. They may not know how to take care of their child or how the illness will affect their family life. Researchers want to study how these parents cope with and adapt to their child s condition in light of this uncertainty. Being uncertain can make it hard for parents to adapt. But it also might give them hope. Researchers want to study how uncertain the parents think their situation is and how that affects the way they think they can cope. Personality traits, like being able to handle uncertainty and being resilient, might also affect coping. Objectives: \- To understand how having a child with an undiagnosed illness affects the way their parents think they can cope. Eligibility: \- Adults with a child who has a medical condition that has not been diagnosed for at least 2 years and involves at least 2 parts of the body. Design:

  • Participants will answer survey questions for about 30 minutes. The questions are about their thoughts and feelings about having a child with an undisclosed illness.
  • Participants can take the survey on paper or online.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
168

participants targeted

Target at P50-P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 12, 2013

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 12, 2013

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

July 18, 2013

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 23, 2013

Completed
Last Updated

April 24, 2026

Status Verified

July 2, 2025

Enrollment Period

Same day

First QC Date

July 18, 2013

Last Update Submit

April 23, 2026

Conditions

Keywords

Undiagnosed Medical ConditionsNatural History

Outcome Measures

Primary Outcomes (3)

  • A

    To assess the dimensions of perceived uncertainty and their relative importance among parents of children with undiagnosed medicalconditions.

    Enrollment

  • B

    To assess the role of uncertainty in predicting coping efficacy among parents of children with undiagnosed medical conditions.

    Enrollment

  • C

    To determine whether tolerance for uncertainty and optimism moderate the relationship between uncertainty and coping efficacy.

    Enrollment

Study Arms (1)

Parent

Persons aged 18 years or older who have a child with an undiagnosed medical condition, who have applied to the Undiagnosed Diseases Network, and have been assigned to the NIH.

Eligibility Criteria

Age18 Years - 115 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants for this study will be English speaking men and women ages 18 years or older who have a child with an undiagnosed medical condition, who have applied to the Undiagnosed Diseases Network, and have been assigned to the NIH.

* Participants for this study will be English speaking men and women ages 18 years or older who have a child with an undiagnosed medical condition who have applied to the Undiagnosed Diseases Network, and have been assigned to the NIH. The participant may be the adoptive or biological parent. Parents may decide between themselves who will complete the survey as only one survey per household will be allowed.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

National Human Genome Research Institute (NHGRI), 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

MeSH Terms

Conditions

Undiagnosed Diseases

Condition Hierarchy (Ancestors)

Disease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Ellen F Macnamara

    National Human Genome Research Institute (NHGRI)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 18, 2013

First Posted

July 23, 2013

Study Start

June 12, 2013

Primary Completion

June 12, 2013

Last Updated

April 24, 2026

Record last verified: 2025-07-02

Locations