Contralateral Strength-training After Anterior Cruciate Ligament (ACL) Reconstruction
Could Contralateral Quadriceps Strength Training Attenuate the Strength Loss in the ACL-operated Knee?
1 other identifier
interventional
36
1 country
1
Brief Summary
The main aims of the study are (1) to examine the impact of contralateral strength training on the quadriceps muscle function after ACL surgery and (2) to compare the magnitude of cross-education induced by NMES versus eccentric strength training.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2013
CompletedFirst Submitted
Initial submission to the registry
May 29, 2013
CompletedFirst Posted
Study publicly available on registry
July 17, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2016
CompletedDecember 19, 2023
December 1, 2023
3.4 years
May 29, 2013
December 18, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Change in bilateral quadriceps muscle strength [Nm]
1-2weeks preoperative/ 2weeks/ 8weeks/ 6month
Change in quadriceps muscle activation
1-2 weeks preoperative/ 2weeks/ 8weeks/ 6month
Secondary Outcomes (3)
Change in muscle architecture
1-2 weeks preoperative/ 2weeks/ 8weeks/ 6month
Change in self-reported questionnaire outcomes (KOOS, WOMAClk)
1-2weeks preoperative/ 2weeks/ 8weeks/ 6 month
functional test outcomes
6month postop
Study Arms (3)
NMES
EXPERIMENTALneuromuscular electrical stimulation (NMES) of the quadriceps muscle with Kneehab
eccentric training
EXPERIMENTALunilateral eccentric resistance exercises
sham NMES
SHAM COMPARATORneuromuscular electrical stimulation of the quadriceps muscle with intensity which causes no visible contraction or displacement of the leg (activation below motor threshold)
Interventions
Eligibility Criteria
You may qualify if:
- patients scheduled for ACL reconstruction surgery
You may not qualify if:
- Concomitant lower limb injury or disorder
- previous lower extremity open surgery on the contralateral lower limb
- cardiac disease
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Neuromuscular Research Laboratory, Schulthess Klinik
Zurich, Canton of Zurich, 8008, Switzerland
Related Publications (2)
Feil S, Newell J, Minogue C, Paessler HH. The effectiveness of supplementing a standard rehabilitation program with superimposed neuromuscular electrical stimulation after anterior cruciate ligament reconstruction: a prospective, randomized, single-blind study. Am J Sports Med. 2011 Jun;39(6):1238-47. doi: 10.1177/0363546510396180. Epub 2011 Feb 22.
PMID: 21343386BACKGROUNDHortobagyi T, Scott K, Lambert J, Hamilton G, Tracy J. Cross-education of muscle strength is greater with stimulated than voluntary contractions. Motor Control. 1999 Apr;3(2):205-19. doi: 10.1123/mcj.3.2.205.
PMID: 10198150BACKGROUND
Study Officials
- PRINCIPAL INVESTIGATOR
Nicola A Maffiuletti, PhD
Schulthess Klinik
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 29, 2013
First Posted
July 17, 2013
Study Start
May 1, 2013
Primary Completion
October 1, 2016
Study Completion
November 1, 2016
Last Updated
December 19, 2023
Record last verified: 2023-12