NCT01901263

Brief Summary

Cognitive and behavioral units (CBUs) have been created between 2008 and 2012 French National Alzheimer plan for the management of behavior problems of patients suffering from Alzheimer's disease or other related disorders and necessitating hospitalisation. This Alzheimer plan is promoting the evaluation of these units through the observation of the behavioral and psychological symptoms of dementia (BPSD) evolution. As these units are new, it appears important to assess their long-term impact on patients care.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
306

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2012

Typical duration for all trials

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2012

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

July 9, 2013

Completed
8 days until next milestone

First Posted

Study publicly available on registry

July 17, 2013

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2015

Completed
Last Updated

December 2, 2015

Status Verified

July 1, 2015

Enrollment Period

3 years

First QC Date

July 9, 2013

Last Update Submit

November 30, 2015

Conditions

Keywords

Cognitive and behavioral unitsAlzheimer DiseaseDementia

Outcome Measures

Primary Outcomes (1)

  • Neuropsychiatric Inventory (NPI) score

    impact of CBU effectiveness in reducing BPSD

    one year

Secondary Outcomes (4)

  • CBU effectiveness in reducing BPSD

    6 months

  • CBU effectiveness on quality of life of patients and caregivers, and on caregivers' burden

    one year

  • Psychotropic drugs (in particular neuroleptic drugs) consumption

    one year

  • rehospitalisation rate for BPSD of the patients in the year following their hospitalisation in CBU

    one year

Study Arms (1)

patient with alzheimer's disease

Cohort of patients with psychological symptoms of dementia hospitalised in Cognitive and Behaviorial Units (CBUs) Evaluation of these units through the observation of the behavioral and psychological symptoms of dementia evolution : NPI score, caregivers quality of life, caregivers burden, collection of psychotropic drugs, the rehospitalisation rate

Behavioral: patients with alzheimer's disease

Interventions

the Neuropsychiatric Inventory (NPI), is uded to assess 10 behavioral disturbances occurring in dementia patients: delusions, hallucinations, dysphoria, anxiety, agitation/aggression, euphoria, disinhibition, irritability/lability, apathy, and aberrant motor activity. The NPI uses a screening strategy to minimize administration time, examining and scoring only those behavioral domains with positive responses to screening questions.

patient with alzheimer's disease

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with Alzheimer's disease or associated disorders and BDSP and hospitalized in a CBU

You may qualify if:

  • patient hospitalized on CBUs
  • patient with the diagnostic criteria for disease related to dementia stage with a Clinical Demential Rating ≥ 1
  • patient with a caregiver who is fairly frequent contact with the patient in order to observe the appearance of behavior changes

You may not qualify if:

  • Patient living alone at home
  • Patient with risk of death within one year

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

CH Saint Jean de Dieu

Lyon, 69373, France

Location

CHU de Saint Etienne

Saint-Etienne, 42000, France

Location

Hospices Civils de Lyon

Villeurbanne, 69100, France

Location

Related Publications (1)

  • Pongan E, Freulon M, Delphin-Combe F, Dibie-Racoupeau F, Martin-Gaujard G, Federico D, Waissi A, Richard G, Jacqueline S, Fabre F, Trombert-Paviot B, Krolak-Salmon P, Laurent B, Rouch I. Initial and long-term evaluation of patients with Alzheimer's after hospitalization in cognitive and behavioural units: the EVITAL study design. BMC Psychiatry. 2014 Nov 15;14:308. doi: 10.1186/s12888-014-0308-6.

MeSH Terms

Conditions

Alzheimer DiseaseDementia

Interventions

Amyloid beta-Protein Precursor

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Amyloidogenic ProteinsAmyloidProteinsAmino Acids, Peptides, and ProteinsMembrane ProteinsProtein PrecursorsProtease NexinsProteinase Inhibitory Proteins, Secretory

Study Officials

  • Isabelle ROUCH, PhD

    CHU de Saint-Etienne

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 9, 2013

First Posted

July 17, 2013

Study Start

October 1, 2012

Primary Completion

October 1, 2015

Study Completion

October 1, 2015

Last Updated

December 2, 2015

Record last verified: 2015-07

Locations