Thalidomide in the Treatment of Chronic Plaque Psoriasis.

You may not qualify if:

• Unstable psoriasis
• Unable or unwilling to meet all criteria for contraception as required in STEPS.
• Known allergy to thalidomide.
• Known history of neuropathy.
• Abnormal laboratory test results that the investigator feels would compromise patient safety or evaluation of drug safety.
• The introduction of drugs for other medical conditions which are known to affect psoriasis (e.g., lithium, beta-adrenergic blockers, etc.) during the period 4 weeks prior to and during the study period.
• Use of any investigational therapy within the 4 weeks prior to the first dose of thalidomide.
• Expectation of exposure to strong sunlight during the course of the study (e.g. planned holiday in high sunlight area) or intention of sunbathing for prolonged periods of time during the course of the study.
• Current drug or alcohol abuse (drug screening not required).
• Medical conditions that preclude thalidomide therapy. Any other condition which, in the judgment of the investigator, would put the subject at unacceptable risk for participation in the study.