Altitude, Exercise and Glucose Metabolism in Pre-diabetic Men

NCT01890876 | Completed

• 1 other identifier: AN5029
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Concentric (CE) and eccentric (EE) exercises may differently affect glucose metabolism which may be additionally modified when exercises are performed in hypoxia, e.g. at moderate (1500 - 2500 m) or high (2500 - 3500 m) altitudes. However, data on the effects of glucose metabolism due to CE and EE in hypoxia are scarce but would be of utmost importance considering the increasing number of persons suffering from impaired glucose tolerance or diabetes and the unique opportunities provided by the mountainous regions of the Alps to perform CE (e.g. uphill hiking) and EE (downhill hiking, downhill skiing) at altitude between 1500 - 3500 m. Metabolic responses to exercise may be largely mediated by interleukin 6 (IL-6), which is predominantly derived from the contracting limbs and may support the maintenance of metabolic homeostasis during exercise. In addition, IL-6 is elevated with acute and chronic altitude exposure at least partly mediated via adrenergic stimulation. Thus, the type of exercise as well as hypoxia may contribute to IL-6 elevations and differences in serum IL-6 concentrations might help to explain distinctions between responses of glucose metabolism to CE and EE at low and moderate to high altitude. 32 male subjects suffering from pre-diabetes will be randomly assigned to a downhill (EE) or uphill (CE) walking group performing 9 sessions at low altitude (860 - 1360 m) and 9 sessions at moderate to high altitude (2000 - 2500 m). Between normoxic and hypoxic condition will be a break of approximately 12 month. Measurements of glucose metabolism, IL-6 plasma concentration will be performed pre, mid (day 5) and post intervention. Moreover anthropometric, strength and exercise capacity characteristics will be performed pre and post intervention. We hypothesize that EE in hypoxia is more effective in the modulation of glycemic control in pre-diabetic men than CE in hypoxia as well as EE and CE in normoxia. It is suggested that effects on glucose metabolism are associated with changes in plasma IL-6 concentrations. EE in hypoxia is expected to result in a more persistent rise of plasma IL-6 concentration than CE in hypoxia and in normoxia and to a more pronounced rise in plasma IL-6 than EE in normoxia.

Conditions

Diabetes

Keywords

glucose tolerance, hypoxia, myokines, exercise

Outcome Measures

Primary Outcomes (1)

• Glucose tolerance

  18 months

Secondary Outcomes (2)

• Myokines

  18 months

• Cardiovascular fitness

  18 months

Study Arms (2)

Low altitude

ACTIVE COMPARATOR

Walking uphill Walking downhill

Other: Walking uphill; Other: Walking downhill

High altitude

ACTIVE COMPARATOR

Walking uphill Walking downhill

Other: Walking uphill; Other: Walking downhill

Interventions

Walking uphill OTHER

ascending about 500 m

High altitude; Low altitude

Walking downhill OTHER

descending about 500 m

High altitude; Low altitude

Eligibility Criteria

• Age: 50 Years - 65 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Pre-diabetes
• male
• age 50-65 years

You may not qualify if:

• smoking
• BMI \> 30 kg/m2
• diseases not compatible with intervention

Sponsors & Collaborators

• Universitaet Innsbruck: lead
• Medical University Innsbruck: collaborator

Study Sites (1)

Department of Sport Science, Medical Section, University of Innsbruck

Innsbruck, 6020, Austria

Location

Related Publications (4)

• Drexel H, Saely CH, Langer P, Loruenser G, Marte T, Risch L, Hoefle G, Aczel S. Metabolic and anti-inflammatory benefits of eccentric endurance exercise - a pilot study. Eur J Clin Invest. 2008 Apr;38(4):218-26. doi: 10.1111/j.1365-2362.2008.01937.x.

  PMID: 18339002 BACKGROUND

• Duennwald T, Gatterer H, Groop PH, Burtscher M, Bernardi L. Effects of a single bout of interval hypoxia on cardiorespiratory control and blood glucose in patients with type 2 diabetes. Diabetes Care. 2013 Aug;36(8):2183-9. doi: 10.2337/dc12-2113. Epub 2013 Mar 27.

  PMID: 23536585 BACKGROUND

• Burtscher M, Gatterer H, Kunczicky H, Brandstatter E, Ulmer H. Supervised exercise in patients with impaired fasting glucose: impact on exercise capacity. Clin J Sport Med. 2009 Sep;19(5):394-8. doi: 10.1097/JSM.0b013e3181b8b6dc.

  PMID: 19741312 BACKGROUND

• Philippe M, Junker G, Gatterer H, Melmer A, Burtscher M. Acute effects of concentric and eccentric exercise matched for energy expenditure on glucose metabolism in healthy females: a randomized crossover trial. Springerplus. 2016 Aug 30;5(1):1455. doi: 10.1186/s40064-016-3062-z. eCollection 2016.

  PMID: 27652031 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus; Hypoxia; Motor Activity

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Martin Burtscher, Professor

  department of sport science, medical section, university innsbruck

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Univ.-Prof. Mag. DDr. Martin Burtscher

Study Record Dates

• First Submitted: June 27, 2013
• First Posted: July 2, 2013
• Study Start: June 1, 2013
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2015
• Last Updated: January 22, 2019

Record last verified: 2019-01

Locations

AU (1)