Bioenergetics in Surgical Patients

NCT01890395 | Unknown

• 1 other identifier: 12-294
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

To identify patients who may be predisposed for developing MOF (multiple organ failure)by the sampling of blood.

Conditions

Mitochondrial DAMP Levels in Surgical Patients

Keywords

mitochondrial DAMPS

Outcome Measures

Primary Outcomes (1)

• correlation mitochondrial damps (mDAMPS) and multiple organ system failure

  Preliminary studies (at University of South Alabama)in the trauma and burn patients indicate that the level of mitochondrial damps are highly correlated with non-survival; that is, they reflect a massive trauma. They also reflect patients that have a propensity to go into multiple system organ failure. We believe that these measurements in our surgical patients will also reveal many of the same correlations with the correlation between microvascular circulation and the mitochondrial damps.

  1 year

Study Arms (1)

blood collection

OTHER

procedure: Blood draws as the intervention

Other: Blood draws

Interventions

Blood draws OTHER

Blood sampling collected at 9 timepoints: pre-operative, during surgery X 3, immediately after surgery, 24 hrs post-op, 72 hrs post-op, 5 days and 7 days post

blood collection

Eligibility Criteria

• Age: 19 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients @ USAMC undergoing surgical operations expected to have microcirculatory changes, i.e., CABG, open heart, aortic or other revascularizing operations, general surgical operations such as colon resections, bowel resections or any other surgical procedures in which the subject could be expected to or might develop multiple system organ failure.

You may not qualify if:

• N/A

Sponsors & Collaborators

• University of South Alabama: lead

Study Sites (1)

University of South Alabama Medical Center

Mobile, Alabama, 36617, United States

RECRUITING

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• William O. Richards, MD

  University of South Alabama, Department of Surgery

  PRINCIPAL INVESTIGATOR

Central Study Contacts

William O. Richards, MD

CONTACT

251-471-7993; brichards@usouthal.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: June 26, 2013
• First Posted: July 1, 2013
• Study Start: December 1, 2012
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: August 17, 2018

Record last verified: 2018-08

Locations

US (1)