NCT01886664

Brief Summary

The investigators tried to evaluate the effect of desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation surgery. The investigators used sevoflurane as a comparison.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
70

participants targeted

Target at P25-P50 for phase_4

Timeline
Completed

Started Dec 2012

Shorter than P25 for phase_4

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 20, 2012

Completed
3 months until next milestone

Study Start

First participant enrolled

December 1, 2012

Completed
7 months until next milestone

First Posted

Study publicly available on registry

June 26, 2013

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2013

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2013

Completed
Last Updated

June 26, 2014

Status Verified

June 1, 2014

Enrollment Period

11 months

First QC Date

August 20, 2012

Last Update Submit

June 25, 2014

Conditions

Liver TransplantationPostreperfusion Syndrome

Outcome Measures

Primary Outcomes (1)

  • frequency of PRS

    reperfusion syndrome occurs, if it occurs, immediately after reperfusion. Therefore, the primary outcome, reperfusion syndrome, can only be assessed immediately after reperfusion.

    immediately after reperfusion

Secondary Outcomes (1)

  • ICU length of stay

    after LT until the patient is transferred to the ward

Study Arms (2)

Sevoflurane

ACTIVE COMPARATOR

Performing liver transplantation under general anesthesia using sevoflurane

Drug: sevoflurane

Desflurane

EXPERIMENTAL

Performing liver transplantation under general anesthesia using desflurane

Drug: Desflurane

Interventions

sevofluraneDRUG
Sevoflurane
DesfluraneDRUG
Desflurane

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • elective LDLT

You may not qualify if:

  • age \< 18, age \> 65
  • patient refusal
  • re-transplantation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seoul National University Hospital

Seoul, Seoul, 110-744, South Korea

Location

Related Publications (1)

  • Lee J, Yoo YJ, Lee JM, Park YJ, Ryu HG. Sevoflurane Versus Desflurane on the Incidence of Postreperfusion Syndrome During Living Donor Liver Transplantation: A Randomized Controlled Trial. Transplantation. 2016 Mar;100(3):600-6. doi: 10.1097/TP.0000000000000874.

    PMID: 26335917DERIVED

MeSH Terms

Interventions

SevofluraneDesflurane

Intervention Hierarchy (Ancestors)

Methyl EthersEthersOrganic ChemicalsHydrocarbons, FluorinatedHydrocarbons, HalogenatedHydrocarbonsEthyl Ethers

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 20, 2012

First Posted

June 26, 2013

Study Start

December 1, 2012

Primary Completion

November 1, 2013

Study Completion

December 1, 2013

Last Updated

June 26, 2014

Record last verified: 2014-06

Locations

KR(1)