IOP Lowering Effect of PLT Versus SLT in Naiv OAG Patients
Effect of Patterned Laser Trabeculoplasty on Intraocular Pressure Compared to Selective Laser Trabeculoplasty in Treatment Naiv Patients Suffering From Open-angle Glaucoma or Ocular Hypertension
1 other identifier
interventional
210
1 country
1
Brief Summary
To investigate the effect of patterned laser trabeculoplasty (PLT) compared to selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) in treatment naiv patients suffering from open-angle glaucoma or ocular hypertension. Values for IOP will be measured at baseline, 1 day and 1 month post-interventional as well as 2, 3, 6, 9, 12, 18 and 24 months after treatment.
- Trial with medical device
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2013
CompletedFirst Submitted
Initial submission to the registry
June 21, 2013
CompletedFirst Posted
Study publicly available on registry
June 25, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2017
CompletedJune 25, 2013
June 1, 2013
4 years
June 21, 2013
June 24, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Intraocular pressure 6 months after Intervention
6 months
Study Arms (2)
PLT
EXPERIMENTALpatients treated with patterned laser trabeculoplasty
SLT
ACTIVE COMPARATORpatients treated with selective laser trabeculoplasty
Interventions
Eligibility Criteria
You may qualify if:
- Intraocular pressure (treatment naiv or after 4 weeks wash-out phase) \> 21 mm Hg
- visible angle structures over 360° on gonioscopy
- age = 18 years
You may not qualify if:
- Intraocular Inflammation
- patients who underwent refractive corneal surgery for any reason or who underwent ocular surgery to reduce intraocular pressure (e.g. trabeculectomy)
- monocle situation
- anterior chamber lenses (incl. iris claw)
- secondary glaucoma (with the exception of pseudoexfoliation and pigment dispersion)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Zurich, Ophthalmology Clinic
Zurich, Canton of Zurich, 8091, Switzerland
Related Publications (1)
Rolim-de-Moura CR, Paranhos A Jr, Loutfi M, Burton D, Wormald R, Evans JR. Laser trabeculoplasty for open-angle glaucoma and ocular hypertension. Cochrane Database Syst Rev. 2022 Aug 9;8(8):CD003919. doi: 10.1002/14651858.CD003919.pub3.
PMID: 35943114DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christoph Kniestedt, MD
University Hospital Zurich, Ophthalmology Clinic
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 21, 2013
First Posted
June 25, 2013
Study Start
February 1, 2013
Primary Completion
February 1, 2017
Study Completion
February 1, 2017
Last Updated
June 25, 2013
Record last verified: 2013-06