NCT01884883

Brief Summary

The aim of this study is to confirm the biomechanical effects and evaluate functional benefits of a new knee brace combining valgus inducing effect on medial compartment and leg external rotation during the stance phase in patients with symptomatic medial knee osteoarthritis.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
21

participants targeted

Target at below P25 for not_applicable knee-osteoarthritis

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2010

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2011

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

June 18, 2013

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 24, 2013

Completed
Last Updated

June 24, 2013

Status Verified

June 1, 2013

Enrollment Period

1.6 years

First QC Date

June 18, 2013

Last Update Submit

June 21, 2013

Conditions

Outcome Measures

Primary Outcomes (2)

  • Pain score on visual analogic scale

    Pain was self-evaluated by patient on visual analogic scale (VAS: 0-100, 0 = no pain at all; 100 = worst pain appendix 1). Such pain is widely used and validated in the literature for the evaluation of knee osteoarthritis treatment outcome.

    Baseline

  • Pain score on visual analogic scale

    Pain was self-evaluated by patient on visual analogic scale (VAS: 0-100, 0 = no pain at all; 100 = worst pain appendix 1). Such pain is widely used and validated in the literature for the evaluation of knee osteoarthritis treatment outcome.

    Baseline + 5 weeks

Secondary Outcomes (2)

  • Evaluation of the functional capacities: KOOS questionnaire.

    baseline

  • Evaluation of the functional capacities: KOOS questionnaire.

    baseline + 5 weeks

Study Arms (1)

Internal unicompartmental knee brace

OTHER
Device: PROTEOR Internal unicompartmental knee brace

Interventions

Also known as: trademark : " PROTEOR " : code name 2H-200
Internal unicompartmental knee brace

Eligibility Criteria

Age40 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patient understanding simple order and able to give written consent.
  • Man or woman with age between 40 et 75 years
  • Unilateral medial symptomatic knee osteoarthritis, defined using the American College of Rheumatology classification
  • Radiologic grade II, III ou IV (Kellgren et Lawrence (KL) classification)
  • Medial knee compartment (Medial K\&L g rade higher than lateral K\&L grade
  • Knee pain \> 40/100 on visual analog scale and \<30/100 for the other
  • No change in medical treatment for at least 3 months.

You may not qualify if:

  • Patient without healthcare insurance.
  • Inflammatory knee arthritis,
  • Indication of knee surgery
  • Pregnancy, breastfeeding
  • Associate neurologic or orthopaedic affection that interferes with gait analysis
  • Rapidly destructive arthritis.
  • Alzheimer's disease, Parkinson's disease, motor neuronal disorders
  • Patient under guardianship or tutelage

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Dijon

Dijon, 21079, France

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • Jean-Francis Maillefert

    CHU Dijon - Department of Rheumatology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 18, 2013

First Posted

June 24, 2013

Study Start

May 1, 2010

Primary Completion

December 1, 2011

Last Updated

June 24, 2013

Record last verified: 2013-06

Locations