Exercise-induced Hypoalgesia After Comparative Forms of Exercise

NCT01883895 | Completed Results DMC

• 1 other identifier: 2012-0805
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The study involves recording response to discomfort following different forms of exercise. We think that there will be a increased pain tolerance following exercise but are unsure if there will be a difference between exercises.

Conditions

Pain

Keywords

Pain; exercise-induced hypoalgesia

Outcome Measures

Primary Outcomes (1)

• Change in Pain Intensity Ratings (0-100 Pain Scale)

  Subjects will rate pain intensity using a 0 (no pain) to 100 (most intense pain imaginable) pain rating scale before and after application of a validated pressure stimulator immediately prior to, and after exercise. Ratings will be recorded at 20 second intervals following each administration of the pressure stimulator for a total of 120 seconds. The ratings will then be averaged over all the time points.

  Average pain rating over 120 seconds

Secondary Outcomes (1)

• Pain Threshold

  We will monitor the subject's reported pain thresholds during the two minute interval that the pressure stimulus is applied. Expected average is less than one minute.

Study Arms (1)

exercise treatment

OTHER

Concentric exercise: subject will utilize a dumbbell with elbow flexion exercise. Isometric exercise: Subjects will perform 5 sets of sustained muscle contraction. Control: Subjects will undergo a control arm where they will rest for approximately 10 minutes. Pain testing conducted by Forgionei-Barber pressure pain-stimulator for both the control and exercise treatments.

Device: Forgionei-Barber pressure-pain stimulator; Other: Concentric Exercise; Other: isometric exercise

Interventions

Forgionei-Barber pressure-pain stimulator DEVICE

Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator to deliver 3000-gm force to the middle digit of the non-dominant middle finger for up to 120 seconds. During stimulation, subjects will press a button attached to a timer when the pressure stimulus first becomes painful (pain threshold) and will also rate their perceived pain intensity using a 0-100 numeric pain rating scale at 20 second intervals during the 2 minute exposure to the pressure stimulus. This validated protocol has been used in previous research by investigators in this study. This will be used for both exercise sessions and the control session. Forgionei-Barber pressure-pain stimulator will be used.

exercise treatment

Concentric Exercise OTHER

Concentric testing will utilize a dumbbell with elbow flexion exercise. Subjects will perform 5 sets of 20 reps at 30% MVC. Pain testing will be conducted using a Forgionei-Barber pressure-pain stimulator immediately before and after the exercise.

exercise treatment

isometric exercise OTHER

When undergoing isometric exercise, subjects will perform 5 sets of sustained muscle contraction for 65 seconds using a hand-grip dynamometer. Pain testing will be conducted using a Forgionei-Barber pressure-pain stimulator immediately before and after the exercise.

exercise treatment

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• normotensive
• age range 18 to 40 years

You may not qualify if:

• currently taking prescription medications
• current use of tobacco or recreational drugs including opiates and/or marijuana
• any chronic illness such as diabetes, cancer, fibromyalgia, or hypertension
• upper limb musculoskeletal pain, injury, or surgery that will limit ability to exercise

Sponsors & Collaborators

• University of Wisconsin, Madison: lead

Study Sites (1)

University of Wisconsin Hospitals and Clinics

Madison, Wisconsin, 53705, United States

Location

MeSH Terms

Conditions

Pain

Interventions

Exercise

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Results Point of Contact

• Title: Nalini Sehgal
• Organization: UW Madison

sehgal@rehab.wisc.edu

608-263-8639

Study Officials

• Nalini Sehgal, MD

  University of Wisconsin Dept Ortho/Rehab

  PRINCIPAL INVESTIGATOR

• ben rawson, DO

  University of Wisconsin Dept Ortho/Rehab

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: three treatment design, all participants will perform two exercise sessions (isometric exercise, concentric exercise), as well as a control session in a randomized manner. (This is not a cross-over design as each participant will have their own randomized order of sessions of exercise \& control sessions.)

Study Record Dates

• First Submitted: June 12, 2013
• First Posted: June 21, 2013
• Study Start: June 1, 2013
• Primary Completion: May 1, 2014
• Study Completion: May 1, 2014
• Last Updated: July 24, 2017
• Results First Posted: July 24, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)