Evaluation of Immune Signaling Networks in Healthy Human Volunteers
1 other identifier
observational
25
1 country
1
Brief Summary
The purpose of this study is to better understand whether and to what extent the activity of immune cells in blood varies over time under normal conditions as assessed in healthy subjects. Results of this study will provide the foundation for helping us evaluate changes in immune cell activities in response to surgery and drugs used in anesthesia. The overall purpose of our research is to understand immune health in the context of anesthesia and surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2012
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2012
CompletedFirst Submitted
Initial submission to the registry
June 18, 2013
CompletedFirst Posted
Study publicly available on registry
June 20, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedMay 4, 2016
May 1, 2016
11 months
June 18, 2013
May 2, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Numerical and functional changes of circulating immune cells over time in healthy individuals
This is an exploratory study. Numerical and functional (phosphorylation of signaling molecules and transcription factors) behavior of all circulating immune cells will be captured. Blood specimens collected at referenced time points will be analyzed with mass cytometry.
Day 1, Day 2, Day 7, Day 28
Eligibility Criteria
Study population consists of a community sample.
You may qualify if:
- Age 18-50
- Good general health
You may not qualify if:
- Recent cold or flu
- Chronic use of medications affecting the immune system
- Chronic illness
- Smoking habit
- History of drug abuse
- Current recreational drug use
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Martin Angstlead
Study Sites (1)
Stanford University
Stanford, California, 94305, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Martin S Angst, MD
Stanford University SOM
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor of Anesthesia
Study Record Dates
First Submitted
June 18, 2013
First Posted
June 20, 2013
Study Start
August 1, 2012
Primary Completion
July 1, 2013
Study Completion
July 1, 2013
Last Updated
May 4, 2016
Record last verified: 2016-05