Oral Glucose Stimulation in Normal-weight and Obese Volunteers
Oral Glucose in Normal-weight and Obese Volunteers
1 other identifier
interventional
24
1 country
1
Brief Summary
The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2013
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedFirst Submitted
Initial submission to the registry
May 8, 2013
CompletedFirst Posted
Study publicly available on registry
June 12, 2013
CompletedJune 12, 2013
June 1, 2013
2 months
May 8, 2013
June 11, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Effect of different oral glucose loads on secretion of satiation hormones
Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured
240min.
Secondary Outcomes (1)
Effect of different oral glucose loads on gastric emptying
240min.
Study Arms (3)
Glucose 10g
ACTIVE COMPARATOR10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube
Glucose 25g
ACTIVE COMPARATOR25g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube
Placebo
PLACEBO COMPARATORintragastric tap water
Interventions
Eligibility Criteria
You may qualify if:
- Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of \> 30
- Normal eating habits
- Age 18-40 years
- Stable body weight for at least three months
You may not qualify if:
- Smoking
- Substance abuse
- Regular intake of medications (except for oral contraceptives)
- Medical or psychiatric illness
- Any abnormality detected during the screening procedure
- history of gastrointestinal disorders
- food allergies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Basel
Basel, CH-4031, Switzerland
Related Publications (1)
Meyer-Gerspach AC, Cajacob L, Riva D, Herzog R, Drewe J, Beglinger C, Wolnerhanssen BK. Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One. 2016 Mar 4;11(3):e0150803. doi: 10.1371/journal.pone.0150803. eCollection 2016.
PMID: 26942445DERIVED
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christoph Beglinger, Prof
University Hospital, Basel, Switzerland
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 8, 2013
First Posted
June 12, 2013
Study Start
February 1, 2013
Primary Completion
April 1, 2013
Study Completion
April 1, 2013
Last Updated
June 12, 2013
Record last verified: 2013-06