CTRP3 and Progranulin in Patients With Coronary Artery Disease
Implications of C1q/TNF-related Protein-3(CTRP-3) and Progranulin in Patients With Acutecoronary Syndrome and Stable Angina Pectoris
1 other identifier
observational
362
1 country
1
Brief Summary
Visceral obesity is the one of the major causes of cardiovascular morbidity and mortality in industrialized countries. Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Progranulin and CTRP3 are recently discovered novel adipokines. Therefore, the investigators tried to compare circulating CTRP-3 and progranulin levels in patients with CAD and investigated whether CTRP-3 or progranulin is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2012
CompletedFirst Submitted
Initial submission to the registry
June 2, 2013
CompletedFirst Posted
Study publicly available on registry
June 5, 2013
CompletedSeptember 2, 2020
August 1, 2020
1.8 years
June 2, 2013
August 31, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
CTRP3
CTRP3 (ng/ml)
16 months
Secondary Outcomes (4)
SBP
16 months
LDL cholesterol
16 months
hsCRP
16 months
creatinine
16 months
Study Arms (3)
Acute coronary syndrome (ACS)
Who were admitted to the coronary care units of the division of cardiology at Guro hospital in Korea University Medical Center. They have Acute myocardial infarction or unstable angina.
Stable angina pectoris (SAP)
Who were admitted to the coronary care units of the division of cardiology at Guro hospital in Korea University Medical Center. They have Stable angina.
Control
Who were recruited from the participants for a routine health check-up in the Health Promotion Center of Korea University Guro Hospital.
Eligibility Criteria
Acute coronary syndrome (ACS) patients, who were admitted to the coronary care units of the Division of Cardiology at Guro Hospital in Korea University Medical Center. Control subjects were recruited from the participants for a routine health check-up in the Health Promotion Center of Korea University Guro Hospital.
You may qualify if:
- acute myocardial infarction
- unstable angina
- stable angina pectoris
You may not qualify if:
- For control group, we exclude the participants who had
- a history of CVD (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
- type 2 diabetes
- stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
- malignancy
- severe renal or hepatic disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Korea Universitylead
Study Sites (1)
Korea University Guro Hospital Dept. of Endocrinology
Seoul, South Korea
Biospecimen
Blood samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kyung Mook Choi, M.D.
Korea University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
June 2, 2013
First Posted
June 5, 2013
Study Start
March 1, 2011
Primary Completion
December 31, 2012
Study Completion
December 31, 2012
Last Updated
September 2, 2020
Record last verified: 2020-08