Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients

NCT01867853 | Completed DMC

• 1 other identifier: 10286
• Study Type: observational
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the performance of volume responsiveness in predicting the outcome of mechanical ventilation weaning in critically ill patients.

Conditions

Weaning Failure

Outcome Measures

Primary Outcomes (1)

• changes of cardiac index

  30 minutes

Study Arms (2)

successful weaning

the SUCCESS of SBT or not need for reintubation or noninvasive ventilation within 48 h following extubation

Device: PLR

failed weaning

the failure of SBT or the need for reintubation or noninvasive ventilation within 48 h following extubation

Device: PLR

Interventions

PLR DEVICE

passive leg raising test was done before and at the end of SBT

Also known as: passive leg raising

failed weaning; successful weaning

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patients were mechanically ventilated and ready to undergo a spontaneous breathing trial (SBT) with a T-piece

You may qualify if:

• mechanical ventilation

You may not qualify if:

• pregnancy or breast-feeding
• tracheostomy at baseline
• myasthenia gravis or acute polyradiculoneuropathy
• end-stage chronic illness

Sponsors & Collaborators

• Southeast University, China: lead
• Zhongda Hospital: collaborator

Study Sites (1)

Zhongda hospital

Nanjing, Jiangsu, 210009, China

Location

Related Publications (6)

• MacIntyre N. Discontinuing mechanical ventilatory support. Chest. 2007 Sep;132(3):1049-56. doi: 10.1378/chest.06-2862.

  PMID: 17873200 RESULT

• Eskandar N, Apostolakos MJ. Weaning from mechanical ventilation. Crit Care Clin. 2007 Apr;23(2):263-74, x. doi: 10.1016/j.ccc.2006.12.002.

  PMID: 17368170 RESULT

• MacIntyre NR, Cook DJ, Ely EW Jr, Epstein SK, Fink JB, Heffner JE, Hess D, Hubmayer RD, Scheinhorn DJ; American College of Chest Physicians; American Association for Respiratory Care; American College of Critical Care Medicine. Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest. 2001 Dec;120(6 Suppl):375S-95S. doi: 10.1378/chest.120.6_suppl.375s. No abstract available.

  PMID: 11742959 RESULT

• Monnet X, Teboul JL, Richard C. Cardiopulmonary interactions in patients with heart failure. Curr Opin Crit Care. 2007 Feb;13(1):6-11. doi: 10.1097/MCC.0b013e328013c865.

  PMID: 17198043 RESULT

• Teboul JL, Monnet X. Detecting volume responsiveness and unresponsiveness in intensive care unit patients: two different problems, only one solution. Crit Care. 2009;13(4):175. doi: 10.1186/cc7979. Epub 2009 Aug 10.

  PMID: 19678915 RESULT

• Monnet X, Teboul JL. Passive leg raising. Intensive Care Med. 2008 Apr;34(4):659-63. doi: 10.1007/s00134-008-0994-y. Epub 2008 Jan 23.

  PMID: 18214429 RESULT

Study Officials

• Zhimin DOU

  Southeast University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: May 6, 2013
• First Posted: June 4, 2013
• Study Start: October 1, 2012
• Primary Completion: March 1, 2013
• Study Completion: March 1, 2013
• Last Updated: June 5, 2013

Record last verified: 2013-06

Locations

CN (1)