Role of ASICs in Human Inflammatory Pain

NCT01867840 | Unknown

• 1 other identifier: 12-PP-07
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity, which is a major cause of pain. Indeed, many painful conditions such as ischemia, inflammation, tumor development or tissue incision are accompanied by tissue acidification. ASIC are excitatory ion channels that are expressed in neurons, including nociceptive sensory neurons. In humans, the use of amiloride, a nonspecific inhibitor of ASICs, has demonstrated their role in the perception of pain induced by subcutaneous injections of acidic solutions. ASICs thus appear as new candidates capable of mediating pain in humans. A growing number of data suggests that, in addition to protons, ASICs may also be activated by one or more endogenous compounds produced during inflammation. The purpose of this research project is to identify these compounds by testing the effects of human inflammatory exudates on ASICs activity. The discovery of such compounds would definitely validate ASICs as novel therapeutic targets for pain treatment in humans

Conditions

Arthritis; Osteoarthritis; Chondrocalcinosis; Gouty Arthritis; Rheumatoid Arthritis

Outcome Measures

Primary Outcomes (1)

• activation or miodulation to Electrical potential of ionic channel in the synovial fluid

  only once because it's an single ponction of sinovial fluid.

  1 day

Study Arms (1)

arthritis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

(osteoarthritis, chondrocalcinosis, gouty arthritis, rheumatoid arthritis)

You may qualify if:

• septic arthritis
• gonarthrosis in push-inflammatory
• microcrystalline arthropathies
• chronic inflammatory rheumatism

You may not qualify if:

• refusal to participate in the protocol

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

Service de Rhumatologie

Nice, Nice, 06000, France

RECRUITING

Related Publications (1)

• Khoury S, Colas J, Breuil V, Kosek E, Ahmed AS, Svensson CI, Marchand F, Deval E, Ferreira T. Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases. Biomolecules. 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342.

  PMID: 36830710 DERIVED

MeSH Terms

Conditions

Arthritis; Osteoarthritis; Chondrocalcinosis; Arthritis, Gouty; Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Crystal Arthropathies; Gout; Purine-Pyrimidine Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Metabolic Diseases; Nutritional and Metabolic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Véronique BREUIL, Pr

  service de rhumatologie

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Véronique BREUIL, Pr

CONTACT

0492035512; breuil.v@chu-nice.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 15, 2013
• First Posted: June 4, 2013
• Study Start: November 1, 2012
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2018
• Last Updated: October 21, 2016

Record last verified: 2016-10

Locations

FR (1)