Study Stopped
Study was terminated in order to secure the data quality of the study in terms of follow-up rates and data completeness.
Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients
TIGRIS
TIGRIS: Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable Coronary Artery dISease in Post Myocardial Infarction Patients
1 other identifier
observational
9,284
25 countries
309
Brief Summary
THis study is intended to provide contemporary data on the burden of disease in patients 1 to 3 years post-MI, including a description of patient characteristics, current treatment patterns, rate of major CV events, and healthcare resource utilization in a 'real world' patient population at high atherothrombotic risk.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2013
Typical duration for all trials
309 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 29, 2013
CompletedFirst Posted
Study publicly available on registry
June 3, 2013
CompletedStudy Start
First participant enrolled
June 19, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2017
CompletedSeptember 4, 2018
August 1, 2018
3.8 years
May 29, 2013
August 30, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
MI, unstable angina with urgent revascularization, stroke, and death for any cause
Event rates (time to first occurrence of any event from the composite of MI, unstable angina with urgent revascularization, stroke or death for any cause) in a three-year follow-up period.
in a 3-year follow-up period
Healthcare resource utilization
Healthcare resource utilization associated with the events (MI, unstable angina with urgent revascularization, stroke or death for any cause) in a three-year follow-up period.
in a 3-year follow-up period
Secondary Outcomes (2)
Ischemic events (MI, unstable angina with urgent revascularization, ischemic stroke, CV death or death with unknown reason)
in a 3-year follow-up period
Bleeding events which require medical attention
in a 3 year follow-up period
Study Arms (1)
Stable CAD patients aged 50 years or older
Stable CAD patients aged 50 years or older with documented history of presumed spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and have at least 1 additional risk factor
Eligibility Criteria
Stable CAD patients aged 50 years or older with documented history of presumed spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and at least one additional risk factor for atherothrombotic events
You may qualify if:
- \- Stable CAD patients aged 50 years or older with documented history of presumed spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and have at least 1 of the following risk factors: age ≥ 65 years; diabetes mellitus requiring medication; documented history of a second prior presumed spontaneous MI (\>1 year ago); documented history of angiographic evidence of multivessel coronary artery disease; chronic renal dysfunction.
You may not qualify if:
- Presence of serious co-morbidities in the opinion of the investigator which may limit life expectancy (\<1 year)
- Current participation in a blinded randomized clinical trial.
- Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient
- Patients receiving treatment of ticagrelor beyond 12 months, or off label use of ticagrelor.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (309)
Research Site
Huntsville, Alabama, United States
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Los Angeles, California, United States
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Santa Ana, California, United States
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Torrance, California, United States
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Ventura, California, United States
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Clearwater, Florida, United States
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Miami, Florida, United States
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Tallahassee, Florida, United States
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Tucker, Georgia, United States
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Arlington Heights, Illinois, United States
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Englewood, Illinois, United States
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Lebanon, Indiana, United States
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Auburn, Maine, United States
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Bangor, Maine, United States
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Columbia, Maryland, United States
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Jackson, Michigan, United States
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Minneapolis, Minnesota, United States
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Manhasset, New York, United States
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Chapel Hill, North Carolina, United States
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Durham, North Carolina, United States
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Sandusky, Ohio, United States
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Abington, Pennsylvania, United States
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Doylestown, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Sayre, Pennsylvania, United States
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Providence, Rhode Island, United States
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Jackson, Tennessee, United States
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Houston, Texas, United States
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Plano, Texas, United States
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Burlington, Vermont, United States
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Falls Church, Virginia, United States
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Manassas, Virginia, United States
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Seattle, Washington, United States
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Spokane, Washington, United States
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Buenos Aires, Argentina
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Corrientes, Argentina
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Córdoba, Argentina
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Mendoza, Argentina
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Salta, Argentina
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Santa Fe, Argentina
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Coffs Harbour, New South Wales, Australia
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Concord, New South Wales, Australia
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Kogarh, New South Wales, Australia
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Liverpool, New South Wales, Australia
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Newcastele, New South Wales, Australia
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St Leonards, New South Wales, Australia
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Wollongong, New South Wales, Australia
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Brisbane, Queensland, Australia
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Nambour, Queensland, Australia
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Southport, Queensland, Australia
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Woolloongabba, Queensland, Australia
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Epping, Victoria, Australia
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Parkville, Victoria, Australia
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Richmond, Victoria, Australia
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Fremantle, Western Australia, Australia
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Nedlands, Western Australia, Australia
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Aalst, Belgium
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Bonheiden, Belgium
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Brasschaat, Belgium
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Brussels, Belgium
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Genk, Belgium
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Ghent, Belgium
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Kortrijk, Belgium
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Ostend, Belgium
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Overpelt, Belgium
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Veurne, Belgium
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Campo Grande, Mato Grosso do Sul, Brazil
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Blumenal, Santa Cantarina, Brazil
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Marília, São Paulo, Brazil
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São José do Rio Preto, São Paulo, Brazil
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Saint John, New Brunswick, Canada
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Brampton, Ontario, Canada
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Cambridge, Ontario, Canada
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Hamilton, Ontario, Canada
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London, Ontario, Canada
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Newmarket, Ontario, Canada
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North York, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Greenfield Park, Quebec, Canada
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Montreal, Quebec, Canada
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Saint-Jérôme, Quebec, Canada
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Thetford-Mines, Quebec, Canada
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Québec, Canada
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Beijing, Beijing Municipality, China
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Chongqing, Chongqing Municipality, China
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Lanzhou, Gansu, China
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Guangzhou, Guangdong, China
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Nanjing, Jiangsu, China
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Wuxi, Jiangsu, China
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Zhenjiang, Jiangsu, China
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Changchun, Jilin, China
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Jinzhou, Liaoning, China
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Jinan, Shandong, China
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Shanghai, Shanghai Municipality, China
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Xian, Shanxi, China
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Taiyuan, Shanyuan, China
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Tianjin, Tianjin Municipality, China
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Kunming, Yunnan, China
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Medellín, Antioquia, Colombia
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Barranquilla, Atlántico, Colombia
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Cartagena, Caldas Department, Colombia
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Manizales, Caldas Department, Colombia
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Bucaramanga, Santander Dept, Colombia
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Cali, Valle del Cauca Department, Colombia
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Aalborg, Denmark
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Arhus N, Denmark
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Copenhagen, Denmark
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Haderslev, Denmark
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Hellerup, Denmark
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København NV, Denmark
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København S, Denmark
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Randers, Denmark
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Jyväskylä, Finland
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Rovaniemi, Finland
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Tampere, Finland
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Turku, Finland
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Abbeville, France
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Arras, France
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Boulogne-Billancourt, France
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Briis Sous Forge, France
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Corbeille Essone, France
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Dijon, France
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La Rochelle, France
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Langres, France
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Le Chesnay, France
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Le Coudray, France
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Lyon, France
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Marseille, France
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Nice, France
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Roubaix, France
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Salouël, France
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Toulouse, France
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Berlin, Germany
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Bochum, Germany
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Chemnitz, Germany
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Cloppenburg, Germany
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Coburg, Germany
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Cologne, Germany
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Dresden, Germany
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Erfurt, Germany
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Erlangen, Germany
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Essen, Germany
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Frankfurt, Germany
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Frankfurt M, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Kiel, Germany
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Koblenz, Germany
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Leipzig, Germany
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Leverkusen, Germany
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Ludwigshafen, Germany
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Lübeck, Germany
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Mainz, Germany
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Merseburg, Germany
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Mönchengladbach, Germany
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München, Germany
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Potsdam, Germany
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Soltau, Germany
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Stuttgart, Germany
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Ulm, Germany
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Hyderabad, Andhra Pradesh, India
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Surat, Gujarat, India
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Bangalore, Karnataka, India
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Thrisur, Kerala, India
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Trivandrum, Kerala, India
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Indore, Madhya Pradesh, India
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Mumbai, Maharashtra, India
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Pune, Maharashtra, India
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New Delhi, National Capital Territory of Delhi, India
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Mohali, Punjab, India
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Jaipur, Rajasthan, India
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Chennai, Tamil Nadu, India
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Madurai, Tamil Nadu, India
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Noida, Uttar Pradesh, India
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Kolkata, West Bengal, India
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Ancona, Italy
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Bologna, Italy
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Catania, Italy
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Lagosanto FE, Italy
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Lido di Camaiore, Italy
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Massa Carrara, Italy
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Milan, Italy
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Napoli, Italy
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Nuoro, Italy
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Palermo, Italy
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Perugia, Italy
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Prato, Italy
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Sassari, Italy
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Treviso, Italy
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Toyoake-shi, Aichi-ken, Japan
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Chiba, Chiba, Japan
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Kisarazu-shi, Chiba, Japan
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Matsuyama, Ehime, Japan
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Fukui-shi, Fukui, Japan
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Fukuoka, Fukuoka, Japan
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Kurume-shi, Fukuoka, Japan
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Maebashi, Gunma, Japan
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Hiroshima, Hiroshima, Japan
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Sapporo, Hokkaido, Japan
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Tomakomai-shi, Hokkaido, Japan
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Amagasaki-shi, Hyōgo, Japan
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Kanazawa, Ishikawa-ken, Japan
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Morioka, Iwate, Japan
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Isehara-shi, Kanagawa, Japan
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Sagamihara-shi, Kanagawa, Japan
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Yokohama, Kanagawa, Japan
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Kochi, Kochi, Japan
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Kumamoto, Kumamoto, Japan
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Sendai, Miyagi, Japan
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Tenri-shi, Nara, Japan
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Hirakata-shi, Osaka, Japan
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Osaka, Osaka, Japan
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Suita-shi, Osaka, Japan
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Kusatsu-shi, Shiga, Japan
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Izunokuni-shi, Shizuoka, Japan
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Shizuoka, Shizuoka, Japan
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Komatsujima-shi, Tokushima, Japan
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Bunkyo-ku, Tokyo, Japan
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Chuo-Ku, Tokyo, Japan
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Wakayama, Wakayama, Japan
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Torreón, Coahuila, Mexico
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Tijuana, Estado de Baja California, Mexico
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Guadalajara, Jalisco, Mexico
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Mexico City, Mexico City, Mexico
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Querétaro City, Querétaro, Mexico
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Toluca, State of Mexico, Mexico
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Chihuahua City, Mexico
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Oaxaca City, Mexico
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Puebla City, Mexico
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San Luis Potosí City, Mexico
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Amsterdam, Netherlands
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Arnhem, Netherlands
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Blaricum, Netherlands
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Delft, Netherlands
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Doetinchem, Netherlands
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Ede, Netherlands
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Groningen, Netherlands
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Haarlem, Netherlands
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Hardenberg, Netherlands
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Heerlen, Netherlands
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Hoofddorp, Netherlands
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Hoogeveen, Netherlands
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IJssel, Netherlands
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Meppel, Netherlands
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Sittard-Geleen, Netherlands
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The Hague, Netherlands
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Zutphen, Netherlands
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Fredrikstad, Norway
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Oslo, Norway
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Stavanger, Norway
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Braga, Portugal
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Canelas, Portugal
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Faro, Portugal
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Lisbon, Portugal
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Porto, Portugal
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Senhora da Hora, Portugal
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Setúbal, Portugal
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Viana do Castelo, Portugal
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Arad, Romania
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Brăila, Romania
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Bucharest, Romania
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Cluj-Napoca, Romania
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Craiova, Romania
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Drobeta-Turnu Severin, Romania
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Focşani, Romania
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Piteşti, Romania
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Sibiu, Romania
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Slatina, Romania
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Timișoara, Romania
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Chungcheongbuk-do, Cheongju-si, South Korea
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Wŏnju, Gangwon-do, South Korea
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Jinju, Gyeongsangnam-do, South Korea
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Jeonju, Jeollabuk-do, South Korea
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Gwangju, Jeollanam-do, South Korea
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Daejeon, Jung-gu, South Korea
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Daegu, Nam-gu, South Korea
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Busan, Seo-gu, South Korea
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Seoul, Sudogwon, South Korea
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Seville, Andalusia, Spain
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Palma de Mallorca, Balearic Islands, Spain
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Toledo, Castille-La Mancha, Spain
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Barcelona, Catalonia, Spain
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Vic, Catalonia, Spain
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Cáceres, Extremadura, Spain
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Santiago de Compostela, Galicia, Spain
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Baza, Granada, Spain
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Alicante, Spain
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Almería, Spain
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Granada, Spain
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Lleida, Spain
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Madrid, Spain
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Murcia, Spain
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Ankara, Turkey (Türkiye)
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Aydin, Turkey (Türkiye)
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Diyarbak?r, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Merkez, Turkey (Türkiye)
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Mersin, Turkey (Türkiye)
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Airdrie, United Kingdom
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Cambridge, United Kingdom
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East Kilbride, United Kingdom
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London, United Kingdom
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Portadown, United Kingdom
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Sheffield, United Kingdom
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Taunton, United Kingdom
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Wolverhampton, United Kingdom
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Valencia, Carabobo, Venezuela
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Caracas, Miranda, Venezuela
Related Publications (9)
Krishnamurthy SN, Pocock S, Kaul P, Owen R, Goodman SG, Granger CB, Nicolau JC, Simon T, Westermann D, Yasuda S, Andersson K, Brandrup-Wognsen G, Hunt PR, Brieger DB, Cohen MG. Comparing the long-term outcomes in chronic coronary syndrome patients with prior ST-segment and non-ST-segment elevation myocardial infarction: findings from the TIGRIS registry. BMJ Open. 2023 Dec 18;13(12):e070237. doi: 10.1136/bmjopen-2022-070237.
PMID: 38110389DERIVEDNicolau JC, Owen R, Furtado RHM, Goodman SG, Granger CB, Cohen MG, Westermann D, Yasuda S, Simon T, Hedman K, Hunt PR, Brieger DB, Pocock SJ. Long-term outcomes among stable post-acute myocardial infarction patients living in rural versus urban areas: insights from the prospective, observational TIGRIS registry. Open Heart. 2023 Aug;10(2):e002326. doi: 10.1136/openhrt-2023-002326.
PMID: 37604649DERIVEDBagai A, Ali FM, Gregson J, Alexander KP, Cohen MG, Sundell KA, Simon T, Westermann D, Yasuda S, Brieger D, Goodman SG, Nicolau JC, Granger CB, Pocock S. Multimorbidity, functional impairment, and mortality in older patients stable after prior acute myocardial infarction: Insights from the TIGRIS registry. Clin Cardiol. 2022 Dec;45(12):1277-1286. doi: 10.1002/clc.23915. Epub 2022 Nov 1.
PMID: 36317424DERIVEDCarnicelli AP, Owen R, Pocock SJ, Brieger DB, Yasuda S, Nicolau JC, Goodman SG, Cohen MG, Simon T, Westermann D, Hedman K, Andersson Sundell K, Granger CB. Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction. Open Heart. 2021 Dec;8(2):e001726. doi: 10.1136/openhrt-2021-001726.
PMID: 34911791DERIVEDRusso JJ, Yan AT, Pocock SJ, Brieger D, Owen R, Sundell KA, Bagai A, Granger CB, Cohen MG, Yasuda S, Nicolau JC, Brandrup-Wognsen G, Westermann D, Simon T, Goodman SG. Determinants of long-term dual antiplatelet therapy use in post myocardial infarction patients: Insights from the TIGRIS registry. J Cardiol. 2022 Apr;79(4):522-529. doi: 10.1016/j.jjcc.2021.10.024. Epub 2021 Nov 29.
PMID: 34857432DERIVEDPocock S, Brieger DB, Owen R, Chen J, Cohen MG, Goodman S, Granger CB, Nicolau JC, Simon T, Westermann D, Yasuda S, Hedman K, Mellstrom C, Andersson Sundell K, Grieve R. Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis. Open Heart. 2021 Feb;8(1):e001499. doi: 10.1136/openhrt-2020-001499.
PMID: 33563776DERIVEDNicolau JC, Brieger D, Owen R, Furtado RHM, Goodman SG, Cohen MG, Simon T, Westermann D, Granger CB, Grieve R, Yasuda S, Chen J, Hedman K, Mellstrom C, Brandrup-Wognsen G, Pocock SJ. Diabetes association with self-reported health, resource utilization, and prognosis post-myocardial infarction. Clin Cardiol. 2020 Dec;43(12):1352-1361. doi: 10.1002/clc.23476. Epub 2020 Nov 4.
PMID: 33146924DERIVEDWestermann D, Goodman SG, Nicolau JC, Requena G, Maguire A, Chen JY, Granger CB, Grieve R, Pocock SJ, Blankenberg S, Vega AM, Yasuda S, Simon T, Brieger D; TIGRIS Study Investigators. Rationale and design of the long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study. Clin Cardiol. 2017 Dec;40(12):1197-1204. doi: 10.1002/clc.22837. Epub 2017 Dec 16.
PMID: 29247524DERIVEDGoodman SG, Nicolau JC, Requena G, Maguire A, Blankenberg S, Chen JY, Granger CB, Grieve R, Pocock SJ, Simon T, Yasuda S, Vega AM, Brieger D; TIGRIS Study Investigators. Longer-term oral antiplatelet use in stable post-myocardial infarction patients: Insights from the long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease (TIGRIS) observational study. Int J Cardiol. 2017 Jun 1;236:54-60. doi: 10.1016/j.ijcard.2017.02.062. Epub 2017 Feb 21.
PMID: 28268087DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Lin Zhang, M.D., PhD
AstraZeneca GMA
- PRINCIPAL INVESTIGATOR
David Brieger, MBBS, PhD
Concord Repatriation General Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 29, 2013
First Posted
June 3, 2013
Study Start
June 19, 2013
Primary Completion
March 31, 2017
Study Completion
March 31, 2017
Last Updated
September 4, 2018
Record last verified: 2018-08