The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia

NCT01856387 | Unknown

• 1 other identifier: Zekai Tahir Burak
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

Neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammation and endothelial dysfunction. In recent years, it has been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts,may have clinical utility in predicting diseases. An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literature, many studies have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases ). However, little is known about the predictive values of NLR in pregnancy complications. This study aimed to evaluate the potential predictive value of NLR in preeclampsia- eclampsia.

Conditions

Preeclampsia; Eclampsia

Keywords

preeclampsia; eclampsia; prediction; neutrophil-to Lymphocyte ratio

Outcome Measures

Primary Outcomes (1)

• the effect of neutrophil lymphocyte ratio in preeclampsia eclampsia

  during 6 months ,the patients who was recorded with preeclampsi/eclampsia at our hospital ,first trimester whole blood count was taken and neutrophil lymphocyte ratio was calculated and recorded

  up to 6 months

Study Arms (2)

normal pregnancy outcomes

do not expect poor pregnancy outcomes on normal patients

Biological: high neutrophil to lymphocyte ratio; Other: normal neutrophil-to Lymphocyte ratio

adverse pregnancy outcome

high ratio of Neutrophil / lymphocyte ratio may predict preeclampsia eclampsia

Biological: high neutrophil to lymphocyte ratio; Other: normal neutrophil-to Lymphocyte ratio

Interventions

high neutrophil to lymphocyte ratio BIOLOGICAL

adverse pregnancy outcome; normal pregnancy outcomes

normal neutrophil-to Lymphocyte ratio OTHER

adverse pregnancy outcome; normal pregnancy outcomes

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

first trimester pregnant

You may qualify if:

• pregnant women who developing preeclampsia eclampsia at pregnancy

You may not qualify if:

• Known chronically maternal disease multiple pregnancy older than 40 years old

Sponsors & Collaborators

• Zekai Tahir Burak Women's Health Research and Education Hospital: lead

Study Sites (1)

Zekai Tahir Burak Maternity Teaching Hospital

Ankara, Turkey (Türkiye)

RECRUITING

Biospecimen

Retention: NONE RETAINED

whole blood, serum, white cells

MeSH Terms

Conditions

Pre-Eclampsia; Eclampsia

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• ayse kirbas

  Zekai Tahir Burak Women's Health Research and Education Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ayse Kirbas, MD

Study Record Dates

• First Submitted: May 4, 2013
• First Posted: May 17, 2013
• Study Start: May 1, 2013
• Primary Completion: April 1, 2014
• Study Completion: May 1, 2014
• Last Updated: March 18, 2014

Record last verified: 2013-05

Locations

TU (1)