NCT01844050

Brief Summary

Based on the Individualized treatment of diabetes symptoms to evaluate the method of syndrome differentiation treatment of Traditional Chinese medicine.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable type-2-diabetes-mellitus

Timeline
Completed

Started Sep 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2008

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2009

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2009

Completed
3.6 years until next milestone

First Submitted

Initial submission to the registry

April 22, 2013

Completed
9 days until next milestone

First Posted

Study publicly available on registry

May 1, 2013

Completed
Last Updated

June 12, 2019

Status Verified

May 1, 2013

Enrollment Period

1 year

First QC Date

April 22, 2013

Last Update Submit

June 11, 2019

Conditions

Keywords

Chinese herbal medicinediabetes symptoms

Outcome Measures

Primary Outcomes (1)

  • Change from Baseline Total score of diabetes symptoms at 4 weeks

    0 weeks(baseline), 2 weeks, 4 weeks

Secondary Outcomes (2)

  • Change from Baseline Fasting Blood Glucose at 4 weeks

    0 weeks(baseline), 2 weeks, 4 weeks

  • Change from Baseline blood glucose at 2 hours after meal at 4 weeks

    0 weeks(baseline), 2 weeks, 4 weeks

Study Arms (2)

Chinese herbal medicine

EXPERIMENTAL

Individualized Treatment with Chinese herbal

Drug: Chinese herbal medicine

Placebo

PLACEBO COMPARATOR

Individualized Treatment with placebo Chinese herbal which Containing 2% of Chinese herbal medicine.

Drug: Placebo

Interventions

According to the traditional Chinese medicine syndrome of subject to make up a prescription within the 35 kinds of chosen Chinese herbal medicine, and the dosage without limitation.

Chinese herbal medicine
Placebo

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Newly diagnosed type 2 diabetes poorly controlled by diet and exercise therapy, and must with any of diabetes symptoms.
  • After the diet and exercise therapy, 7.0mmol/l≤FPG≤11.1mmol/l or 8.0mmol/l\<2h PG\<16mmol/l
  • Any type of TCM syndrome, but can be performed within the chosen Chinese herbal medicine.
  • Subject is willing to participate and capable of giving informed consent.

You may not qualify if:

  • Those patients used any drugs for treatment of diabetes within one month.
  • Patients with any severe complications of cardiac, cerebric, vascular, hepatic, renal, blood system.
  • Patients suffer from acute metabolic disorder including diabetic ketoacidosis or hyperosmotic non-ketotic coma within one month.
  • Women who were pregnant, lactating or planned pregnant.
  • Allergic constitution and has a history of drug allergy.
  • Combined with severe acute or chronic infections.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shanghai University of Traditional Chinese Medicine

Shanghai, Shanghai Municipality, 201108, China

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Kaixian Chen, Ph.D

    Shanghai Universitu of TCM

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 22, 2013

First Posted

May 1, 2013

Study Start

September 1, 2008

Primary Completion

September 1, 2009

Study Completion

October 1, 2009

Last Updated

June 12, 2019

Record last verified: 2013-05

Locations