Minimum Effective Concentration of Bupivacaine in Ultrasound-guided Axillary Brachial Plexus Block
1 other identifier
interventional
46
1 country
1
Brief Summary
Background: The use of ultrasound in regional anesthesia enables a reduction in the local anesthetic volume. The present study aimed to determine the minimum effective concentration (EC50 and EC95) of bupivacaine for axillary brachial plexus block (ABPB). Methods: Following approval by the Research Ethics Committee, patients with a physical condition of I or II according to the American Society of Anesthesiologists, between 21 and 65 years of age were recruited and subjected to elective surgery of the hand and ABPB. The concentration of the anesthetic was determined using a step-up/step-down method and was based on the outcome of the preceding block.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable pain
Started Aug 2010
Typical duration for not_applicable pain
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2012
CompletedFirst Submitted
Initial submission to the registry
April 22, 2013
CompletedFirst Posted
Study publicly available on registry
April 24, 2013
CompletedApril 24, 2013
April 1, 2013
4 months
April 22, 2013
April 23, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Minimum effective concentration of bupivacaine in ultrasound-guided axillary brachial plexus block
2 years
Study Arms (1)
Bupivacaine
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- patients with a physical condition of I or II according to the American Society of Anesthesiologists,
- between 18 and 65 years of age
- unilateral hand surgery
- BMI\< 35 kg;m@
You may not qualify if:
- contraindication to regional anesthesia
- bleeding diathesis
- inability to visualize one or more nerves in the axilla
- psychiatric history
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Federal University of Sao Paulo
São Paulo, São Paulo, 04024-002, Brazil
Related Publications (1)
Takeda A, Ferraro LH, Rezende AH, Sadatsune EJ, Falcao LF, Tardelli MA. Minimum effective concentration of bupivacaine for axillary brachial plexus block guided by ultrasound. Braz J Anesthesiol. 2015 May-Jun;65(3):163-9. doi: 10.1016/j.bjane.2013.11.007. Epub 2015 Feb 16.
PMID: 25925026DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Leonardo HC Ferraro, M.D.
Federal University of São Paulo
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- M.D.
Study Record Dates
First Submitted
April 22, 2013
First Posted
April 24, 2013
Study Start
August 1, 2010
Primary Completion
December 1, 2010
Study Completion
June 1, 2012
Last Updated
April 24, 2013
Record last verified: 2013-04