the Effect of Universal Salt Iodization on Thyroid Diseases

NCT01838629 | Completed

• 1 other identifier: 20090833B27
• Study Type: observational
• Target: 12,438
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.acquire the environmental iodine status of Hangzhou
2. 2.acquire the iodine status of population in Hangzhou
3. 3.acquire the prevalence of thyroid diseases in Hangzhou
4. 4.explore the association between iodized salt and thyroid disease

Conditions

Thyroid Nodule

Outcome Measures

Primary Outcomes (1)

• thyroid nodule

  An ultrasound examination of the thyroid was performed to detect thyroid nodules, using a Sonoline Versa Pro (Siemens, Munich, Germany) with a 7.5-MHz, 70-mm linear transducer (effective length, 62 mm).

  8:00am (day 1)

Study Arms (1)

thyroid nodule

Eligibility Criteria

• Age: 6 Years - 86 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study was conducted in Hangzhou, Zhejiang Province, China, which locates at east of China. This city covers eight districts and five counties. There are 8.7 millions residents in Hangzhou city; 73.25% of them living in urban areas, 26.75% in rural areas. This study was designed to be representative of the civilian from Hangzhou and collected information on demographic characteristics, health status, iodine intake and thyroid disease.

You may qualify if:

• age ≥ 6 years old;
• living for above 5 years at present residence.

You may not qualify if:

• resident with coronary angiography (CAG) or endoscopic retrograde cholangiopancreatography (ERCP) in 6 months;
• resident taking amiodarone drug;
• resident with abnormal kidney function or serious illness

Sponsors & Collaborators

• Weimin Xu: lead

Study Sites (1)

Hangzhou Center of Disease Control and Prevention

Hangzhou, Zhejiang, 310000, China

Location

Related Publications (2)

• Xu W, Chen Z, Li N, Liu H, Huo L, Huang Y, Jin X, Deng J, Zhu S, Zhang S, Yu Y. Relationship of anthropometric measurements to thyroid nodules in a Chinese population. BMJ Open. 2015 Dec 21;5(12):e008452. doi: 10.1136/bmjopen-2015-008452.

  PMID: 26692553 DERIVED

• Chen Z, Xu W, Huang Y, Jin X, Deng J, Zhu S, Liu H, Zhang S, Yu Y. Associations of noniodized salt and thyroid nodule among the Chinese population: a large cross-sectional study. Am J Clin Nutr. 2013 Sep;98(3):684-92. doi: 10.3945/ajcn.112.054353. Epub 2013 Jul 10.

  PMID: 23842457 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

The participants were invited to local community health center before 8:00 am after 8-hour fasting overnight. Firstly, each participant provided 10 ml spot urine samples. Then, 5 ml venous blood was collected using vacuum blood collection tube.

MeSH Terms

Conditions

Thyroid Nodule

Condition Hierarchy (Ancestors)

Thyroid Neoplasms; Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms; Endocrine System Diseases; Thyroid Diseases

Study Officials

• Weimin Xu

  Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Superintendent of Department of Endemic Diseases Control and Prevention,Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China

Study Record Dates

• First Submitted: April 19, 2013
• First Posted: April 24, 2013
• Study Start: July 1, 2009
• Primary Completion: June 1, 2012
• Study Completion: June 1, 2012
• Last Updated: May 7, 2013

Record last verified: 2013-05

Locations

CN (1)