NCT01838018|Completed
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Sponsor study identifier
observational
10
1 country
1
Study Start
April 2013
Actual (reported)Primary Completion
October 2017
Actual (reported)Study Completion
January 2018
Actual (reported)The purpose of this study is to learn whether blood flow in the brain is normal in people with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN, may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other brain regions as well as to healthy controls.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2013
Actual (reported)April 18, 2013
Actual (reported)April 23, 2013
Actual (reported)October 2017
Actual (reported)January 2018
Actual (reported)ASL-derived cerebral blood flow(CBF)
The unit of analyses will be the subject and the primary comparison will be the globus pallidus CBF between PKAN and healthy controls.
Single MRI
This group consists of individuals diagnosed with PKAN using a combination of MRI and PANK2 gene sequencing.
This is a control group of healthy volunteers, matched with the PKAN group for age and sex.
The PKAN group consists of individuals in the United States diagnosed with PKAN.
Oregon Health & Science University
Portland, Oregon, 97239, United States
Susan J Hayflick, MD
Oregon Health and Science University
10 participants (actual enrollment reported by the registry).
First Submitted
April 18, 2013
First Posted
April 23, 2013
Study Start
April 2013
Actual (reported)Efficacy and Safety Study of Fosmetpantotenate (RE-024) in PKAN Participants
Contact the study team to confirm eligibility.
Primary Completion
October 2017
Actual (reported)Study Completion
January 2018
Actual (reported)Last Updated
May 29, 2018
Record last verified: 2018-05
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Source: ClinicalTrials.gov.
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