Sweet Cheeks: How Early Nutrition Affects Oral Microbiota Populations and Disease Incidence

NCT01836952 | Completed

• 1 other identifier: 11621
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary and oral hygiene habits are known to affect oral microorganisms and disease incidence, but most research has focused on preschool aged (2-4 yr old) children. A recent experiment in our lab demonstrated a highly diverse oral microbiome in the saliva of infants without teeth (3-6 months old). These data suggest that soft tissues in the mouth serve as a reservoir for pathogens and must be considered in oral health management. The evolution of microorganisms that occurs between birth and tooth eruption has not been characterized and may have great implications as it pertains to oral disease later in life. The investigators are interested in determining how dietary changes during this time affect oral microbiota. Tongue and cheek swab samples will be collected from a small cohort of infants (n=20) at 4 time points. At the same time, a survey and 3 day feeding diary of the infant's diet will be collected. In addition, a pregnancy survey and food frequency questionnaire will be administered at the time of recruitment. Research staff will conduct a 10-minute interview at the first and last oral sample collection time. These pilot data will provide important diet-oral microbe relationships in edentulous infants, allowing us to propose and test specific hypotheses pertaining to diet, oral microbes, and disease in young children.

Conditions

Health Behavior

Outcome Measures

Primary Outcomes (1)

• Oral Bacteria

  2 swabs of the tongue and 2 of the cheeks will be obtained at birth, 2 months of age, 4 months of age, and 6 months of age

  birth to 6 months of age

Study Arms (1)

Infants

Infant born via vaginal delivery

Eligibility Criteria

• Age: 2 Days - 7 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Full term infants born via vaginal delivery

You may qualify if:

• Women must deliver vaginally a full term baby (37 weeks or later). Women must have a healthy pregnancy without medical complications. Women must breastfeed their baby for a period of time after birth (greater than 1 week), followed by introduction of formula.

You may not qualify if:

• Women must not have smoked during their pregnancy,nor have any serious medical conditions during their pregnancy.
• Infants can not be born via cesarean section.
• In addition, the infant should not have any chronic medical conditions and not taking any regular medications.
• full term infant
• healthy infant
• initially breastfed by mother

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead

Study Sites (1)

University of Illinois

Urbana, Illinois, 61801, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Oral swabs of tongue and cheeks. Bacterial DNA to be extracted, no human DNA will be extracted

MeSH Terms

Conditions

Health Behavior

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Kelly Swanson, PhD

  UIUC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 17, 2013
• First Posted: April 22, 2013
• Study Start: October 1, 2012
• Primary Completion: March 1, 2016
• Study Completion: March 1, 2016
• Last Updated: October 31, 2016

Record last verified: 2016-10

Locations

US (1)