Respirophasic Carotid Artery Peak Velocity Variation as a Predictor of Fluid Responsiveness in Patients With Coronary Disease
1 other identifier
interventional
40
1 country
1
Brief Summary
The aim of this study is to investigate usefulness of the respirophasic variation in carotid artery peak flow velocity measured by Doppler ultrasound, which is noninvasive and easily accessible, as a predictor of fluid responsiveness in patients with coronary artery disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Dec 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedFirst Submitted
Initial submission to the registry
April 10, 2013
CompletedFirst Posted
Study publicly available on registry
April 19, 2013
CompletedApril 19, 2013
April 1, 2013
1 year
April 10, 2013
April 18, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Predictive power of the respirophasic carotid flow peak velocity variation for the fluid responsiveness
After induction of anesthesia, peak velocity of carotid artery blood flow is measured by the pulsed wave Doppler signal obtained from the left common carotid artery. Respirophasic variation of the peak velocity is defined as the difference between the maximum and the minimum values of peak velocity divided by the mean of the two values during one respiratory cycle. Fluid responder is defined as a patient whose stroke volume index is increased ≥15% after volume expansion. The receiver operating characteristic curve analysis to descriminiate fluid responder is performed.
Measurement of respirophasic carotid flow peak velocity variation before the volume expansion
Study Arms (1)
fluid responsiveness
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- \. patients scheduled for elective isolated off-pump coronary artery bypass graft surgery
You may not qualify if:
- cardiac rhythm other than sinus
- congestive heart failure
- left ventricular ejection fraction \<35%
- history of transient ischemic attack
- pre-existing cerebrovascular disease and peripheral arterial occlusive disease
- presence of carotid artery stenosis \>50%
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Yonsei University College of Medicine
Seoul, Seoul, 120-752, South Korea
Related Publications (1)
Song Y, Kwak YL, Song JW, Kim YJ, Shim JK. Respirophasic carotid artery peak velocity variation as a predictor of fluid responsiveness in mechanically ventilated patients with coronary artery disease. Br J Anaesth. 2014 Jul;113(1):61-6. doi: 10.1093/bja/aeu057. Epub 2014 Apr 9.
PMID: 24722322DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 10, 2013
First Posted
April 19, 2013
Study Start
December 1, 2011
Primary Completion
December 1, 2012
Study Completion
December 1, 2012
Last Updated
April 19, 2013
Record last verified: 2013-04