Cognitive Hyper-performance - Effects of Stimulating Substances in Chess-players

NCT01834547 | Completed Phase 1 DMC

• 1 other identifier: 1234
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Effects of caffeine, methylphenidate, modafinil and placebo on cognitive performance of chess players in chess games and neuropsychiatric standardized tests. We hypothesize that substances will change cognitive performance in chess players leading to changed results in chess games and neuropsychiatric tests.

Conditions

Cognitively Healthy Subjects Influenced by Psychoactive Drugs

Keywords

chess, cognition

Outcome Measures

Primary Outcomes (1)

• Chess games (win/ lose/ tie)

  two years

Secondary Outcomes (4)

• time period for decision of chess games

  results of ches games

• Cognitive performance measured with standardized neuropsychiatric tests (Tower of Hanoi, Trail-Making test, Stroop-Test, Psycho-Motor-Vigilance test, Wisconsin-Card-Sorting-Test, Balloon Analog Risk Task)

  outcome of tests

• measuring of risk taking behaviour, motivation, mood using standardized questionnaires

  outcome of tests

• adverse events

  type of adverse events

Study Arms (4)

Methylphenidate

EXPERIMENTAL

Methylphenidate

Drug: Drugs use: methylphenidate

modafinil

EXPERIMENTAL

modafinil

Drug: Drug use: modafinil

caffeine

EXPERIMENTAL

caffeine

Drug: caffeine

placebo

PLACEBO COMPARATOR

placebo

Drug: placebo

Interventions

Drugs use: methylphenidate DRUG

40 mg tablets

Methylphenidate

Drug use: modafinil DRUG

40 mg tablets

modafinil

caffeine DRUG

400 mg

caffeine

placebo DRUG

placebo

placebo

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• male
• years old
• existence of ELO-number

You may not qualify if:

• physical diseases (e.g. diabetes mellitus, etc.) with necessity of using prescription drugs
• psychiatric diseases (e.g. psychosis, bipolar disorders, etc.) with necessity of using prescription drugs
• addiction of psychoactive substances
• smoker or quitter (\< 5 years)
• use of more than 5 cups of coffee per day
• irregular day-night-rhythm (e.g. shift workers)

Sponsors & Collaborators

• K. Lieb: lead

Study Sites (1)

Department of Psychiatry and Psychotherapy

Mainz, 55131, Germany

Location

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof. Dr. med. K. Lieb

Study Record Dates

• First Submitted: May 25, 2011
• First Posted: April 18, 2013
• Study Start: May 1, 2011
• Primary Completion: April 1, 2013
• Study Completion: April 1, 2013
• Last Updated: April 18, 2013

Record last verified: 2013-04

Locations

DE (1)