Autonomic Dysfunction in Resistant Hypertension

NCT01833429 | Completed

• 1 other identifier: 907/2011
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.

Conditions

Hypertension, Resistant to Conventional Therapy

Keywords

Resistant hypertension; White-coat phenomenon; Heart rate variability; autonomic activity

Outcome Measures

Primary Outcomes (1)

• evaluation of the autonomic function in resistant hypertensive patients

  The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability. In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours

  10 months

Study Arms (1)

Resistant Hypertension

The current definition of resistant hypertension (RH) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications and those whose BP is controlled when using four or more antihypertensive medications

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Forty-four resistant hypertension subjects, regularly followed up at the cardiovascular clinical pharmacology out-patients' clinic, and who complied with pharmacological prescription for hypertension, were recruited to participate in this transversal and observational study.

You may qualify if:

• resistant hypertensive patients

You may not qualify if:

• White-coat hypertension
• obstructive sleep apnea

Sponsors & Collaborators

• University of Campinas, Brazil: lead

Study Sites (1)

Cardiovascular Pharmacology Laboratory

Campinas, São Paulo, 13083-888, Brazil

Location

Related Publications (2)

• Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM; American Heart Association Professional Education Committee. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008 Jun 24;117(25):e510-26. doi: 10.1161/CIRCULATIONAHA.108.189141.

  PMID: 18574054 RESULT

• Muxfeldt ES, Fiszman R, de Souza F, Viegas B, Oliveira FC, Salles GF. Appropriate time interval to repeat ambulatory blood pressure monitoring in patients with white-coat resistant hypertension. Hypertension. 2012 Feb;59(2):384-9. doi: 10.1161/HYPERTENSIONAHA.111.185405. Epub 2012 Jan 3.

  PMID: 22215711 RESULT

MeSH Terms

Conditions

Hypertension Resistant to Conventional Therapy

Study Design

• Study Type: observational
• Observational Model: COHORT
• Target Duration: 10 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: April 5, 2013
• First Posted: April 16, 2013
• Study Start: September 1, 2011
• Primary Completion: November 1, 2012
• Study Completion: December 1, 2012
• Last Updated: April 16, 2013

Record last verified: 2012-02

Locations

BR (1)