NCT01831128

Brief Summary

The purpose of FACE study is to provide in routine practice complementary long-term data on the mortality and morbidity of Chronic Heart Failure (CHF) patients with Central Sleep Apnea eligible for Adaptative Servo-Ventilation (ASV) treatment (PaceWave, AutoSet CS; ResMed).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
509

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2009

Longer than P75 for all trials

Geographic Reach
1 country

18 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2009

Completed
3.4 years until next milestone

First Submitted

Initial submission to the registry

April 2, 2013

Completed
13 days until next milestone

First Posted

Study publicly available on registry

April 15, 2013

Completed
7.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2020

Completed
Last Updated

February 2, 2021

Status Verified

February 1, 2021

Enrollment Period

10.8 years

First QC Date

April 2, 2013

Last Update Submit

February 1, 2021

Conditions

Keywords

Congestive Heart FailureCentral Sleep ApneaSleep-Disordered Breathing

Outcome Measures

Primary Outcomes (3)

  • Time to first event of all cause mortality or unplanned hospitalization for worsening heart failure

    2 years

  • Time to first event of cardiovascular mortality or unplanned hospitalization for worsening heart failure

    2 years

  • Time to first event of all cause mortality or all cause hospitalization

    2 years

Secondary Outcomes (17)

  • Time until death

    2 years

  • Time to non cardiovascular death

    2 years

  • Time to cardiovascular death

    2 years

  • Time to hospitalization due to deterioration of heart failure or cardiovascular death

    2 years

  • Time to hospitalization for other reasons or death

    2 years

  • +12 more secondary outcomes

Study Arms (2)

ASV Treatment

AutoSet CS, PaceWave

Device: ASV Treatment

Control

No ASV treatment

Interventions

Also known as: PaceWave, AutoSet CS
ASV Treatment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Chronic Heart Failure Patients with Central Sleep Apnea

You may qualify if:

  • Adult Patient with Chronic Heart Failure
  • Central Sleep Apnea requiring ASV therapy

You may not qualify if:

  • Contra-indications to ASV therapy
  • Respiratory Failure or Hypercapnia inconsistent with ASV therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (18)

Medical practice of cardiology

Amnéville, 57360, France

Location

Angers University Hospital

Angers, 49100, France

Location

Antibes Hospital

Antibes, 06160, France

Location

Béziers Hospital

Béziers, 34500, France

Location

Cannes Hospital

Cannes, 06400, France

Location

Henri-Mondor University Hospital

Créteil, 94000, France

Location

Grenoble University Hospital

Grenoble, 38000, France

Location

Le Mans Hospital

Le Mans, 72037, France

Location

HCL - Croix-Rousse Hospital

Lyon, 69004, France

Location

Jacques Cartier Hospital

Massy, 91300, France

Location

Arnaud de Villeneuve University Hospital

Montpellier, 34000, France

Location

Nevers Hospital

Nevers, 58033, France

Location

APHP - Pitié-Salpêtrière University Hospital

Paris, 75013, France

Location

APHP - Bichat-Claude Bernard Hospital

Paris, 75018, France

Location

Bordeaux University Hospital

Pessac, 33604, France

Location

Poitiers University Hospital

Poitiers, 86021, France

Location

Saint Laurent Polyclinic

Rennes, 35706, France

Location

Toulouse University Hospital

Toulouse, 31000, France

Location

Related Publications (2)

  • Tamisier R, Damy T, Bailly S, Goutorbe F, Davy JM, Lavergne F, Palot A, Verbraecken JA, d'Ortho MP, Pepin JL; FACE investigators; Steering committee members; d'Ortho MP, Pepin JL, Davy JM, Damy T, Tamisier R; FACE study investigators. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort. Sleep Med. 2024 Jan;113:412-421. doi: 10.1016/j.sleep.2023.07.014. Epub 2023 Jul 22.

  • Tamisier R, Damy T, Davy JM, Verbraecken JA, Bailly S, Lavergne F, Palot A, Goutorbe F, Pepin JL, d'Ortho MP. Cohort profile: FACE, prospective follow-up of chronic heart failure patients with sleep-disordered breathing indicated for adaptive servo ventilation. BMJ Open. 2020 Jul 19;10(7):e038403. doi: 10.1136/bmjopen-2020-038403.

MeSH Terms

Conditions

Sleep Apnea, CentralHeart FailureSleep Apnea Syndromes

Condition Hierarchy (Ancestors)

ApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesHeart DiseasesCardiovascular Diseases

Study Officials

  • Marie-Pia d'ORTHO, MD, PhD

    APHP (Assistance Publique Hôpitaux de Paris) - Bichat-Claude Bernard Hospital, Paris

    PRINCIPAL INVESTIGATOR
  • Jean-Louis PEPIN, MD, PhD

    Grenoble University Hospital, Grenoble

    STUDY CHAIR
  • Jean-Marc DAVY, MD, PhD

    Arnaud de Villeneuve University Hospital, Montpellier

    STUDY CHAIR
  • Thibaud DAMY, MD, PhD

    APHP - Henri Mondor University Hospital, Creteil

    STUDY CHAIR
  • Patrick LEVY, MD, PhD

    Grenoble University Hospital, Grenoble

    STUDY CHAIR
  • Renaud TAMISIER, MD, PhD

    Grenoble University Hospital, Grenoble

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 2, 2013

First Posted

April 15, 2013

Study Start

November 1, 2009

Primary Completion

September 1, 2020

Study Completion

September 1, 2020

Last Updated

February 2, 2021

Record last verified: 2021-02

Locations