Differential Plasma MicroRNA Profiles in ED and Normal Erectile Function in Older Males
2 other identifiers
observational
30
1 country
1
Brief Summary
Erectile dysfunction (ED) is strongly associated with aging. With the rapidly expanding aging population and the increase in life expectancy, an increase in the prevalence of ED is expected in the years to come. Currently, the mechanism of ED is not fully understood. MicroRNAs (MiRNA) are endogenous small RNA molecules that control gene expression post-transcriptionally. It has been included in many in vitro physiology and pathophysiology processes, which also involved in the process of ED. This research was designed to investigate the differential plasma MiRNA profiles in ED and normal erectile function in older males. The results might tell us which MiRNA and how did it involved in the process of ED in aging.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Mar 2013
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2013
CompletedFirst Submitted
Initial submission to the registry
April 9, 2013
CompletedFirst Posted
Study publicly available on registry
April 11, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2013
CompletedApril 11, 2013
April 1, 2013
4 months
April 9, 2013
April 10, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Gene chips
30 days
Secondary Outcomes (1)
RT-PCR
15 days
Study Arms (3)
Group I
Older males with ED
Group II
Older males with normal erectile function
Gourp III
Young males with normal rectile function
Interventions
Eligibility Criteria
Group I: older males came to our clinic for diagnosis and treatment of ED. Group II: older males came to our clinic for physical examination and the erectile function was normal. Group III: young males came to our clinic for physical examination and the erectile function was normal.
You may qualify if:
- older males with erectile dysfunction
You may not qualify if:
- have some other general diseases, e.g. hypertension, vascular diseases, depression, chronic kidney disease, diabetes.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Nanjing Gulou Hospital affiliated to Nanjing University, Medical School
Nanjing, Jiangsu, 210000, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD.
Study Record Dates
First Submitted
April 9, 2013
First Posted
April 11, 2013
Study Start
March 1, 2013
Primary Completion
July 1, 2013
Study Completion
August 1, 2013
Last Updated
April 11, 2013
Record last verified: 2013-04