NCT01825096|Completed
Simultaneous FMRI and NIRS to Estimate Brain Cerebral Metabolism
Multi-Modal fMRI/NIRS for Estimation of CMRO2 for Neuroimaging Studies of Drug Abuse and Psychiatric Illness Problems
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Multi-Modal fMRI/NIRS for Estimation of CMRO2 for Neuroimaging Studies of Drug Abuse and Psychiatric Illness Problems
Sponsor study identifier
observational
1
1 country
1
Study Start
March 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2015
Actual (reported)Study Completion
December 2015
Actual (reported)The principal advantages of functional magnetic resonance imaging (fMRI) with blood-oxygenation- level-dependent (BOLD) contrast for studying brain function are: non-invasiveness, ubiquitous availability, relatively high spatiotemporal resolution, and the ability to map function over the entire brain. Thus, BOLD fMRI is the most widely applied technology to study healthy brain function and pathophysiology associated with disease. In studies of drug abuse and psychiatric illness though, normal assumptions mapping BOLD signals to neurometabolism may be violated. Generally, these effects are ignored, resulting in large study-to-study variability. Quantitative fMRI (qfMRI) measures metabolism directly and is more suitable for studies of drug abuse and psychiatric illness. However, qfMRI is too complex for routine use. Cerebral metabolism during brain activation during visual stimulation measured with a new fMRI approach that is simple enough for clinical applications will be compared to CMRO2 activation measured using standard qfMRI.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2012
Date type not reportedThis date has not been verified as actual or estimated.
March 27, 2013
Actual (reported)April 5, 2013
Actual (reported)December 2015
Actual (reported)December 2015
Actual (reported)Changes in brain activity associated with visual stimulation
CMRO2 brain activation in visual cortex associated with visual stimulation
cross-sectional, start and up to 6 minutes
No intervention. Participants are scanned at baseline.
1 healthy subject will be recruited for the study from the general population to undergo 12 separate study visits.
McLean Imaging Center
Belmont, Massachusetts, 02478, United States
Lisa D Nickerson, PhD
Mclean Hospital
1 participants (actual enrollment reported by the registry).
First Submitted
March 27, 2013
First Posted
April 5, 2013
Study Start
March 2012
Date type not reportedThis date has not been verified as actual or estimated.
Study to Assess the Effects of Daily Administration of Pioglitazone on Brain Hemodynamics in Healthy Elderly Participants
Contact the study team to confirm eligibility.
Primary Completion
December 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Last Updated
January 5, 2017
Record last verified: 2017-01
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Source: ClinicalTrials.gov.
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