NCT01824888|CompletedPhase 2DMC
Efficacy of JUC as Hand Rub Evaluated by Using European Standard 1500
JUC
The Effectiveness and Efficacy of Using JUC Antimicrobial Spray for Controlling the Infection Transmission
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Sponsor study identifier
Secondary identifiers
OTHER_GRANT · PolyU-Grant-8-ZDA4
interventional
15
1 country
1
Study Start
June 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2012
Actual (reported)Study Completion
December 2012
Actual (reported)JUC is a commercially available wound care spray. It is evaluated for the efficacy when using as a hygienic hand rub following the protocol described in the European standard EN 1500:1997 "Chemical disinfectants and antiseptics - Hygienic handrub - Test method and requirement (phase 2/step 2)". A crossover study to compare the JUC solution with 60% (v/v) propan-2-ol by using Escherichia coli K12 NCTC strain 10538 as test organism.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2012
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2012
Date type not reportedThis date has not been verified as actual or estimated.
August 2012
Actual (reported)December 2012
Actual (reported)March 22, 2013
Actual (reported)April 5, 2013
Actual (reported)Change of Colony forming units on hands from pre-value (baseline) to post-value
Pre-value and post-value were collected by rubbing the fingertips and thumb tips of each hand for 1 minute on the base of a Petri dish containing medium. Then the samples with appropriate dilutions were plated onto agar plates for incubation, and colony forming units of the plates were counted.
Pre-value (baseline) as 0 minutes: at the time after handwashing and before application of JUC or alcohol; Post-value at 5 minutes after the baseline: as after hand contamination, application of JUC or alcohol and drying of hands
Change of colony forming units on hands from baseline to 8 hours after hand rubbing with JUC
Pre-value (baseline) at 0 hour: at the first time after applicaiton of JUC and challenged by the bacteria; Post-values measured at each hour (1,2,3,4,5,6,7 and 8 hours) after the initial application of JUC and bacterial challenge at every hour
Bactericidal efficacy of JUC and neutralizer
1 day
Following standard one-minute handwashing, both hands were immersed up to the mid-metacarpals for 5 seconds into a contamination fluid containing E. coli. Handrubs were performed by using 60% propan-2-ol into the cupped hands and rub vigorously for 30 seconds, the procedure was completed by a 5 seconds rinse of the fingers under running tap water and excess water was shaken off.
Following standard one-minute handwashing, both hands were immersed up to the mid-metacarpals for 5 seconds into a contamination fluid containing E. coli. Handrubs were performed by pouring 1.5 ml of JUC into the cupped hands and rub vigorously for 30 seconds, the procedure was completed by a 5 seconds rinse of the fingers under running tap water and excess water was shaken off.
1.5 ml JUC solution rubbing on hands for 30 seconds, repeated twice
1.5 ml propan-2-ol rubbing on hands for 30 seconds, repeated twice
PolyU Biomedical Science Laboratory
Kowloon, Hong Kong
John Yuen, PhD
The Hong Kong Polytechnic University
15 participants (actual enrollment reported by the registry).
First Submitted
March 22, 2013
First Posted
April 5, 2013
Study Start
June 2012
Date type not reportedThis date has not been verified as actual or estimated.
Eban II: Intervention for HIV Sero-Discordant Couples
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Primary Completion
August 2012
Actual (reported)Study Completion
December 2012
Actual (reported)Last Updated
December 11, 2014
Record last verified: 2014-12
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Source: ClinicalTrials.gov.
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