Effects of Continuous Veno-venous Haemofiltration on Plasma Lactate in Critically Ill Patients

NCT01824771 | Completed DMC

• 1 other identifier: 2013232
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Continuous Veno-Venous Hemofiltration (CVVH) can eliminate metabolic products effectively and replace renal function partly. It is widely used in intensive care units (ICUs), especially for patients with acute kidney injury/failure in an unstable hemodynamic status. Lactate is a molecule smaller than glucose, which can pass through filtration membrane freely in CVVH. Therefore, the blood lactate concentrations would no longer reflect tissue oxygenation status in patients with unstable hemodynamic status. However, there is no prospective study evaluated the effect of CVVH on lactate removal in critically ill patients. The influence of different dose of CVVH on lactate elimination is not clear in patients with different level of serum lactate. Our study aimed to find out how the dose of CVVH effects on lactate clearance, and then re-estimate the prognostic value of lactate in critically ill patients with CVVH.

Conditions

Kidney Injury, Acute

Keywords

Continuous veno-venoous haemofiltration; Plasma lactate; Critical illness; Acute kidney injurytissue perfusion; Multiple organ dysfunction syndrome

Outcome Measures

Primary Outcomes (1)

• plasma lactate

  Each dose of CVVH was lasted for 30 minutes separately. Blood samples were draw pre-(A) and post-dialyzer (V) site after each dosage of CVVH was carried out for 30 minutes and then plasma lactates were measured immediately

  30 minutes

Interventions

Plasma lactate were measured OTHER

Three different doses (20 ml/kg/h, 35 ml/kg/h and 45 ml/kg/h) of CVVH were applied to critically ill patients who experiencing CVVH. Each dose of CVVH was sequentially gave to each patient and lasted for 30 minutes separately

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study was carried out in Surgical Intensive Care Unit (SICU) of the first affiliated hospital, Sun Yat-sen University.The project has been approved by Ethics Committee of Sun Yat-sen University. All the subjects have signed written informed consent.

You may qualify if:

• The critical ill patients with acute kidney injury
• Patients requiring continuous veno-venous hemofiltration
• APACHE II scores more than 12
• Arterial lactate is higher than 0.5mmol/L but lower than 15mmol/L (due to the sensitivity and optimal measuring range of the equipment)
• Continuous veno-venous hemofiltration for at least 12 hrs
• Hemo-filter age of \<24 hrs

You may not qualify if:

• APACHE II scores lower than 12
• patients' age are more than 75Y or lower than 18Y

Sponsors & Collaborators

• First Affiliated Hospital, Sun Yat-Sen University: lead

Study Sites (1)

The first affiliated hospital, Sun Yat-sen University

Guangzhou, Guangdong, 510080, China

Location

Related Publications (1)

• Levraut J, Ciebiera JP, Jambou P, Ichai C, Labib Y, Grimaud D. Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients. Crit Care Med. 1997 Jan;25(1):58-62. doi: 10.1097/00003246-199701000-00013.

  PMID: 8989177 RESULT

MeSH Terms

Conditions

Acute Kidney Injury; Critical Illness; Multiple Organ Failure

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: March 28, 2013
• First Posted: April 5, 2013
• Study Start: March 3, 2013
• Primary Completion: March 3, 2015
• Study Completion: March 20, 2015
• Last Updated: July 27, 2022

Record last verified: 2022-07

Locations

CN (1)