NCT01822145

Brief Summary

The primary hypothesis is that an ICD shock may be predicted days in advance by a combined score derived from different data obtainable from the ICD

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Mar 2013

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2013

Completed
23 days until next milestone

First Submitted

Initial submission to the registry

March 24, 2013

Completed
9 days until next milestone

First Posted

Study publicly available on registry

April 2, 2013

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2016

Completed
Last Updated

September 4, 2015

Status Verified

September 1, 2015

Enrollment Period

2.8 years

First QC Date

March 24, 2013

Last Update Submit

September 3, 2015

Conditions

Keywords

implantable-cardioverter-defibrillatorventricular tachycardiaventricular fibrillationsudden cardiac arrest

Outcome Measures

Primary Outcomes (1)

  • ICD-derived T-wave alternans amplitude before ICD shock

    The T-wave alternans amplitude before an ICD shock will be measured in mV and compared to the baseline T-wave alternans amplitude

    6 months

Study Arms (1)

ICD recipients

ICD recipients with documented cardiac arrest or ventricular arrhythmias

Device: ICD

Interventions

ICDDEVICE
ICD recipients

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

ICD recipients with documented cardiac arrest, ventricular tachycardia or ventricular fibrillation

You may qualify if:

  • Age ≧ 18 and ≦ 80
  • Patients have documented spontaneous and sustained ventricular arrhythmias in the last six months prior to the enrollment
  • Patients who are in sinus rhythm, have dual-chamber ICD or CRT-D implanted at least one month before enrollment
  • Patients who are in atrial fibrillation, have single-chamber ICD or CRT-D implanted at least one month before enrollment
  • Patients who are compliant to CareLink follow-up

You may not qualify if:

  • Patients who are pregnant
  • Patients who are incapable of giving consent to the study
  • Patients who have a life-expectancy of less than 2 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Princess Margaret Hospital

Hong Kong, 999077, China

RECRUITING

MeSH Terms

Conditions

Death, Sudden, CardiacTachycardia, VentricularVentricular Fibrillation

Condition Hierarchy (Ancestors)

Heart ArrestHeart DiseasesCardiovascular DiseasesDeath, SuddenDeathPathologic ProcessesPathological Conditions, Signs and SymptomsTachycardiaArrhythmias, CardiacCardiac Conduction System Disease

Study Officials

  • Ngai Yin Chan, MBBS

    Princess Margaret Hospital, Canada

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ngai Yin Chan, MBBS

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

March 24, 2013

First Posted

April 2, 2013

Study Start

March 1, 2013

Primary Completion

January 1, 2016

Study Completion

January 1, 2016

Last Updated

September 4, 2015

Record last verified: 2015-09

Locations