Assessment of the Effects of Access Count in Percutaneous Nephrolithotomy on Renal Functions by Technetium-99M-Dimercaptosuccinic Acid Scintigraphy

NCT01819753 | Completed

• 1 other identifier: DMSAPCNL
• Study Type: interventional
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

In this study 37 patients who had undergone percutaneous nephrolithotomy were included. Preoperative DMSA scans were performed a day before the surgery, whereas postoperative scans were randomized by evaluating them before (n=25) and after (n=12) the 6th postoperative month. A DMSA scan was read by using a technique that divides both kidneys into three paired poles. In this way functional changes were investigated in the renal units. Twenty six of 37 cases underwent percutaneous nephrolithotomy with a single access site and 11 with multiple access sites. When each of the poles of a kidney was admitted as a surgical unit separately, there were 51 units.

Conditions

Renal Parenchymal Loss After the Percutaneous Nephrolithotomy

Keywords

percutaneous nephrolithotomy; urinary Stones; 99m-Technetium-Dimercaptosuccinic Acid

Outcome Measures

Primary Outcomes (1)

• Renal parenchymal function on DMSA before and after percutaneous nephrolithotomy.

  Preoperative DMSA scans were performed a day before percutaneous nephrolithotomy.How the differential functions with DMSA scans were changed between the sides undergoing PCNL and the opposite sides, as well the changes before and 6 months after surgery are manifested by using these parameters.

  six months

Study Arms (2)

Single access

ACTIVE COMPARATOR

It was performed only single access standard PCNL in this group.

Procedure: Percutaneous nephrolithotomy

Multiple access

ACTIVE COMPARATOR

It was performed multiple access standard PCNL in this group

Procedure: Percutaneous nephrolithotomy

Interventions

Percutaneous nephrolithotomy PROCEDURE

The procedure is done under general anesthesia in the supine position. A Retrograde pyelogram is done to locate the stone in the kidney. With a small incision in the flank, the percutaneous nephrolithotomy (PCN) needle is passed into the pelvis of the kidney. The position of the needle is confirmed by fluoroscopy. A guide wire is passed through the needle into the pelvis. The needle is then withdrawn with the guide wire still inside the pelvis. Over the guide wire the dilators are passed and a working sheath is introduced. A nephroscope is then passed inside and stones are taken out.

Multiple access; Single access

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• \- Patients with renal stones which was bigger than 2cm.

You may not qualify if:

• Patients with acute urinary tract infection,
• Patients with bleeding disorder,
• Patients with chronic renal failure,
• Patients with solitary kidney, renal ectopy or history of any other urinary abnormality.

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes University Faculty of Medicine.

Kayseri, 38039, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Urinary Calculi

Interventions

Nephrolithotomy, Percutaneous

Condition Hierarchy (Ancestors)

Urolithiasis; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Laparoscopy; Endoscopy; Minimally Invasive Surgical Procedures; Surgical Procedures, Operative; Urologic Surgical Procedures; Urogenital Surgical Procedures

Study Officials

• Abdullah Demirtaş, Assistant Prof., MD

  Department of Urology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor., MD

Study Record Dates

• First Submitted: March 25, 2013
• First Posted: March 28, 2013
• Study Start: June 1, 2007
• Primary Completion: June 1, 2009
• Study Completion: June 1, 2009
• Last Updated: March 28, 2013

Record last verified: 2013-03

Locations

TU (1)