Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

NCT01819103 | Completed

• 1 other identifier: 12/WM/0431
• Study Type: observational
• Target: 5,555
• Locations: 0 countries
• Sites: N/A

Brief Summary

To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.

Conditions

Acute Myocardial Infarction

Keywords

Mortality; Acute Myocardial Infarction; Drug Adherence; Drug Compliance; Health-related quality of life

Outcome Measures

Primary Outcomes (1)

• Mortality

  12 months

Secondary Outcomes (1)

• Drug Adherence

  12 month

Other Outcomes (1)

• Health related quality of life assessement

  12 month

Study Arms (1)

Acute myocardial infarction

Drug Adherence

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 5555 consented patients were recruited from acute Trusts in England.

You may qualify if:

• Age \> 18 years, both sexes, acute admission to the acute Trust with suspected acute coronary syndrome (ACS).

You may not qualify if:

• Patients at a terminal stage of any illness, and those in whom follow up would be inappropriate or impractical.

Sponsors & Collaborators

• University of Leeds: lead

Related Publications (4)

• Munyombwe T, Dondo TB, Hall M, Nadarajah R, Hurdus B, Aktaa S, Haris M, Keeley A, West R, Hall A, Norman P, Gale CP. Cohort profile: Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) Longitudinal Cohort. Eur Heart J Qual Care Clin Outcomes. 2023 Aug 7;9(5):442-446. doi: 10.1093/ehjqcco/qcad040.

  PMID: 37451698 DERIVED

• Dondo TB, Munyombwe T, Hall M, Hurdus B, Soloveva A, Oliver G, Aktaa S, West RM, Hall AS, Gale CP. Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study. BMJ Open. 2022 Nov 8;12(11):e062508. doi: 10.1136/bmjopen-2022-062508.

  PMID: 36351712 DERIVED

• Munyombwe T, Dondo TB, Aktaa S, Wilkinson C, Hall M, Hurdus B, Oliver G, West RM, Hall AS, Gale CP. Association of multimorbidity and changes in health-related quality of life following myocardial infarction: a UK multicentre longitudinal patient-reported outcomes study. BMC Med. 2021 Sep 28;19(1):227. doi: 10.1186/s12916-021-02098-y.

  PMID: 34579718 DERIVED

• Munyombwe T, Hall M, Dondo TB, Alabas OA, Gerard O, West RM, Pujades-Rodriguez M, Hall A, Gale CP. Quality of life trajectories in survivors of acute myocardial infarction: a national longitudinal study. Heart. 2020 Jan;106(1):33-39. doi: 10.1136/heartjnl-2019-315510. Epub 2019 Nov 7.

  PMID: 31699696 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood, Urine

MeSH Terms

Conditions

Medication Adherence

Condition Hierarchy (Ancestors)

Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Officials

• Chris P Gale, PhD

  University of Leeds

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: March 23, 2013
• First Posted: March 27, 2013
• Study Start: March 1, 2011
• Primary Completion: February 1, 2013
• Study Completion: March 1, 2013
• Last Updated: April 4, 2013

Record last verified: 2013-04