The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome

NCT01818505 | Unknown DMC

• 1 other identifier: URIC
• Study Type: observational
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated. Many connective tissue diseases such as rheumatoid arthritis are often associated with antiphospholipid antibodies-associated endothelial impairment. In the present study, the investigators will analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. The investigators expect to find a correlation between these pathogenic antibody and those cardiovascular co-morbidities.

Conditions

Antiphospholipid Syndrome; Endothelial Dysfunction; Hyperuricemia; Gout; Metabolic Syndrome

Keywords

antiphospholipid syndrome; gouty arthritis; Hyperuricemia; metabolic syndrome; osteoarthritis; cardiovascular co-morbidities

Outcome Measures

Primary Outcomes (1)

• development of metabolic syndrome or cardiovascular events

  36 months

Secondary Outcomes (1)

• Acute myocardial infarct or stroke

  36 months or more

Study Arms (3)

Gouty arthritis

Patient with gouty arthritis

Asymptomatic hyperuricemia

Patient with asymptomatic hyperuricemia

OA without hyperuricemia

Patient of osteoarthritis but without hyperuricemia and gout

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

General population

You may qualify if:

• Patient with gouty arthritis
• Patient with asymptomatic hyperurecemia
• Patient of osteoarthritis but without hyperuricemia and gout

You may not qualify if:

• Patient younger than 20 y/o.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital Yun-Lin Branch

Dou-Liou City, Yun-Lin County, 640, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Antiphospholipid Syndrome; Hyperuricemia; Gout; Metabolic Syndrome; Arthritis, Gouty; Osteoarthritis

Condition Hierarchy (Ancestors)

Autoimmune Diseases; Immune System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arthritis; Joint Diseases; Musculoskeletal Diseases; Crystal Arthropathies; Rheumatic Diseases; Purine-Pyrimidine Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Metabolic Diseases; Nutritional and Metabolic Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders

Study Officials

• Yu-Min Kuo, MD

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yu-Min Kuo, M.D.

CONTACT

886972655701; 543goole@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2013
• First Posted: March 26, 2013
• Study Start: March 1, 2013
• Primary Completion: December 1, 2015
• Last Updated: April 14, 2014

Record last verified: 2014-04

Locations

TW (1)