NCT01814995

Brief Summary

Women with a history of 'diabetes in pregnancy' or Gestational Diabetes (GDM) have a high risk for type 2 diabetes later in life. This can often be prevented, however, with improvements in eating habits and higher physical activity levels. However, many women find it difficult to alter their lifestyle habits, especially if they have young children. In adults with type 2 diabetes, the investigators have been studying the effects of combining nutrition education with meal preparation training and pedometer-based self-monitoring to improve eating habits and increase activity levels. The investigators have shown that such a strategy can reduce hemoglobin A1C by 0.3% and correlates with small reductions in weight (Dasgupta et al, International Journal of Behavioural Nutrition and Physical Activity, 2012). In developing the present interventional study, we presented this strategy to women with a GDM history and asked them how they would modify it to suit their needs. They expressed strong interest in such an approach but emphasized a need to involve their spouses and provide childcare support. They did not express interest in use of meal replacements. Therefore, in MoMM-intervention phase, the investigators will examine the effects of a once per month (4 session) program combined with Internet/telephone-based support. The four sessions with include meal preparation training, strategies to limit mindless eating and improve meal content and portion control. All sessions will offer child care. Two sessions will involve spouses. The investigators will assess effects on weight, BMI, DXA measures of fat, and measures of insulin resistance and blood pressure. This single-arm intervention study may lead ultimately to a randomized controlled trial.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2012

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

March 18, 2013

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 20, 2013

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2013

Completed
Last Updated

September 11, 2014

Status Verified

September 1, 2014

Enrollment Period

1.7 years

First QC Date

March 18, 2013

Last Update Submit

September 10, 2014

Conditions

Keywords

behaviouraldiabetes preventionoverweightphysical activitygestational diabetes

Outcome Measures

Primary Outcomes (1)

  • percentage change in weight in participant

    Women with a GDM history within the past 5 years are enrolled with a BMI at or above 24 kg/m2. Weight will be measured to the nearest 0.1 kilogram with an automated scale. We will subtract the post intervention weight from the baseline weight to compute the change in weight. We will divide this value by the baseline weight to compute the percentage change in weight from baseline.

    16 to 20 weeks

Secondary Outcomes (33)

  • change in BMI

    16 to 20 weeks

  • change in waist circumference

    16 to 20 weeks

  • change in waist to hip ratio

    16 to 20 weeks

  • change in total body fat

    16 to 20 weeks

  • adbominal adiposity

    16 to 20 weeks

  • +28 more secondary outcomes

Study Arms (1)

Nutrition/Physical Activity Intervention

EXPERIMENTAL

There will be four in-person group sessions (1/month), two including the participants' partners, and all with on-site child care. Sessions will include preparation of a healthy meal (hands-on) and discussions of mindful eating, balanced meals, portion sizes, and preparing food at home, under a dietitian's supervision. Sessions will also include a one-hour physical activity information/practice session with a kinesiologist. Participants will track daily step counts with a pedometer and aim to eventually reach more than 10,000 steps/day. They will also receive instruction and demonstration from a kinesiologist of some simple resistance exercises they may perform at home. Between sessions, participants will receive advice and support through a study-specific website and telephone calls.

Behavioral: Nutrition/Physical Activity Intervention

Interventions

Please see Arm description.

Also known as: Lifestyle Intervention, Diabetes Prevention Intervention
Nutrition/Physical Activity Intervention

Eligibility Criteria

Age18 Years - 55 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Prior history of GDM
  • Body mass index (BMI) ≥ 24 kg/m2
  • Ability to speak and read English or French

You may not qualify if:

  • Type 1 diabetes
  • Type 2 diabetes
  • Use of antihyperglycemic medication
  • Pregnant or planning to become pregnant again in the next year
  • Food allergies
  • Chronic condition/ medications that could impact weight (e.g. malignancy, weight loss medications, anti-depressants)
  • Current smoker

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

McGill University Health Centre

Montreal, Quebec, H3A 1A1, Canada

Location

Sir Mortimer Davis Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada

Location

Related Publications (3)

  • Dasgupta K, Da Costa D, Pillay S, De Civita M, Gougeon R, Leong A, Bacon S, Stotland S, Chetty VT, Garfield N, Majdan A, Meltzer S. Strategies to optimize participation in diabetes prevention programs following gestational diabetes: a focus group study. PLoS One. 2013 Jul 4;8(7):e67878. doi: 10.1371/journal.pone.0067878. Print 2013.

    PMID: 23861824BACKGROUND
  • Leong A, Rahme E, Dasgupta K. Spousal diabetes as a diabetes risk factor: a systematic review and meta-analysis. BMC Med. 2014 Jan 24;12:12. doi: 10.1186/1741-7015-12-12.

    PMID: 24460622BACKGROUND
  • Brazeau AS, Leong A, Meltzer SJ, Cruz R, DaCosta D, Hendrickson-Nelson M, Joseph L, Dasgupta K; MoMM study group. Group-based activities with on-site childcare and online support improve glucose tolerance in women within 5 years of gestational diabetes pregnancy. Cardiovasc Diabetol. 2014 Jun 30;13:104. doi: 10.1186/1475-2840-13-104.

Related Links

MeSH Terms

Conditions

OverweightMotor ActivityDiabetes, Gestational

Interventions

Nutritional Status

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehaviorPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

Nutritional Physiological PhenomenaDiet, Food, and NutritionPhysiological PhenomenaHealth StatusDemographyPopulation Characteristics

Study Officials

  • Kaberi Dasgupta, MD, MSc

    McGill University and McGill University Health Centre

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, McGill University

Study Record Dates

First Submitted

March 18, 2013

First Posted

March 20, 2013

Study Start

January 1, 2012

Primary Completion

September 1, 2013

Study Completion

September 1, 2013

Last Updated

September 11, 2014

Record last verified: 2014-09

Locations