NCT01813916

Brief Summary

The purpose of this study is to use the proteomic analysis of synovial fluid to perform the comprehensive investigation of the biomarker that will be useful to assign the tratment effectiveness of five weekly intra-articular HA injection.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started May 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2008

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2009

Completed
3.8 years until next milestone

First Submitted

Initial submission to the registry

January 30, 2013

Completed
2 months until next milestone

First Posted

Study publicly available on registry

March 19, 2013

Completed
Last Updated

March 19, 2013

Status Verified

March 1, 2013

Enrollment Period

1 year

First QC Date

January 30, 2013

Last Update Submit

March 14, 2013

Conditions

Osteoarthritis

Keywords

Osteoarthritissynovial fluidhyaluronic acid

Outcome Measures

Primary Outcomes (1)

  • To study the protein expression of synovial fluid for hyaluronic acid therapy in osteoarthritis

    We used two-dimensional difference gel electrophoresis (2D-DIGE) combined with matrix-assisted laser desorption ionization time of light mass spectrometry (MALDI-TOF) to determine the differentially displayed proteins in human synovial fluid.

    up to 12 months

Study Arms (1)

proteomic analysis

NO INTERVENTION
Other: proteomic analysis

Interventions

proteomic analysisOTHER
proteomic analysis

Eligibility Criteria

Age40 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Clinical diagnosis of osteoarthritis
  • Accept the intra-articular HA injection therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ccj@Ntu.Edu.Tw

Taipei, Taiwan

Location

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • Ching-Chuan Jiang, M.D.;Ph.D.

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 30, 2013

First Posted

March 19, 2013

Study Start

May 1, 2008

Primary Completion

May 1, 2009

Study Completion

May 1, 2009

Last Updated

March 19, 2013

Record last verified: 2013-03

Locations

TW(1)