Interleukin-1 Receptor Antagonist Gene Polymorphism and Adverse Pregnancy Outcome in Turkish Women

NCT01812083 | Completed DMC

• 2 other identifiers: SelcukUSUDHF1451
• Study Type: observational
• Target: 156
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators hypothesized that the IL-1A (+4895), IL-1B (+3954), and IL-1RN gene polymorphisms may be associated with PLBW. Smoking has been well documented by numerous studies as a major environmental risk factor for periodontitis and adverse pregnancy outcomes. Therefore, the investigators only selected non-smoking individuals in this study as the smoking-related risk could obscure the polymorphism-related increase in risk for periodontitis and adverse pregnancy outcomes. This study aimed to determine the association between IL-1A (+4895), IL-1B (+3954), and IL-1RN polymorphisms with adverse pregnancy outcomes and periodontitis in a non-smoking Turkish population.

Conditions

Periodontitis

Keywords

Periodontitis; adverse pregnancy outcomes; IL-1 polymorphism

Outcome Measures

Primary Outcomes (1)

• Interleukin-1 receptor antagonist gene polymorphism and adverse pregnancy outcome in Turkish women

  5 months

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women between 18-35 years of age with single gestation and with ≥20 on-crowded teeth excluding third molars were included in this study. Subjects were divided into normal birth (NB) and PLBW groups on the basis of their pregnancy outcome. Women who delivered an infant with a birth weight of more than 2500 g after 37 weeks of gestation were placed in the NB group. Women who delivered infants whose birth weight was below 2500 g or before 37 weeks of gestation were placed in the PLBW group.

You may qualify if:

• Subjects were divided into normal birth (NB) and PLBW groups on the basis of their pregnancy outcome. Women who delivered an infant with a birth weight of more than 2500 g after 37 weeks of gestation were placed in the NB group.

Sponsors & Collaborators

• Selcuk University: lead

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Nilgün Özlem Alptekin, DDS,PhD,Prof

  Selcuk University Faculty of Dentistry

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dental Faculty

Study Record Dates

• First Submitted: March 13, 2013
• First Posted: March 15, 2013
• Study Start: January 1, 2004
• Primary Completion: June 1, 2004
• Study Completion: February 1, 2005
• Last Updated: March 15, 2013

Record last verified: 2013-03