The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome
Key Technology Research of the Comprehensive Treatment of Multiple Organ Dysfunction Syndrome
1 other identifier
observational
1
1 country
1
Brief Summary
The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality. It is reported that the mortality rates have varied between 20% and 100%, depending on number, severity, duration, type and combination, and definition of dysfunction. In our study, the investigators explore some comprehensive treatment technology to improved outcomes of MODS patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jan 2009
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2009
CompletedFirst Submitted
Initial submission to the registry
February 27, 2013
CompletedFirst Posted
Study publicly available on registry
March 4, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2013
CompletedMarch 4, 2013
February 1, 2013
4.9 years
February 27, 2013
March 1, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
the prognostic assessment of aged patients with MODS
According to the outcomes of 28-day,all the enrolled patients were divided into survival group and death group, clinical datum of which were collected and analysed. And then these prognosis were evaluated with the current scoring systems \[(Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ, APACHE Ⅲ), Sample Acute Physiological score(SAPSⅡ), Multiple Organ Dysfunction score(MODS)\], the predictive power of which were compared by receiver operating characteristic(ROC) curve. Finally, a binary logistic regression analysis was performed to evaluate the concerning prognostic factors of MODSE.
28 days
Eligibility Criteria
All subjects were selected from among inpatients who were hospitalized between Jan 2009 and May 2013 in the Respiratory Intensive Care Unit(RICU),Surgical Intensive Care Unit(SICU) and Emergency Intensive Care Unit(EICU).
You may qualify if:
- age \> 60 years old;
- presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention;
- have trachea intubation after admitting to intensive care unit within 24 hours.
You may not qualify if:
- end stage multiple organ failure.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chinese PLA General Hospital
Beijing, Beijing Municipality, 100853, China
Related Publications (1)
Xiao K, Su L, Han B, Guo C, Feng L, Jiang Z, Wang H, Lin Y, Jia Y, She D, Xie L. Prognosis and weaning of elderly multiple organ dysfunction syndrome patients with invasive mechanical ventilation. Chin Med J (Engl). 2014;127(1):11-7.
PMID: 24384417DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Key Technology Research of the comprehensive treatment of Multiple organ dysfunction syndrome
Study Record Dates
First Submitted
February 27, 2013
First Posted
March 4, 2013
Study Start
January 1, 2009
Primary Completion
December 1, 2013
Study Completion
December 1, 2013
Last Updated
March 4, 2013
Record last verified: 2013-02