Vitamin D Levels in Patients With Central Retinal Vein Occlusion- a Prospective Controlled Study

NCT01793181 | Completed

• 1 other identifier: 201149311
• Study Type: observational
• Target: 216
• Locations: 1 country
• Sites: 1

Brief Summary

Retinal vein occlusion (RVO) is a common vascular disease of the eye. Studies have shown that the risk of venous thrombosis is higher in winter so even concerning RVO. Studies have shown a possible link between sun exposure and venous thrombosis. Vitamin D levels have been shown to have a similar seasonal variation, with a peak occurring in the summer. The primary source of vitamin D is from sunlight when ultraviolet B (UVB) radiation penetrates the skin and converts 7-dehydrocholesterol to 25-hydroxycholecalciferol vitamin D3 (25-OHVitD) via previtamin D. In Stockholm situated at latitude 59˚ 20΄ North, it is not possible to synthesize vitamin D at sufficient levels in winter and the exposure time required to reach a standard dose is impractical from at least October through March. The aim of the study is to evaluate vitamin D levels in central retinal vein occlusion (CRVO) patients and compare them with the vitamin D levels in randomly selected control patients matched for age and month of disease onset. This is to evaluate whether vitamin D deficiency may be a risk factor in the onset of CRVO. The hypothesis of the study is that patients with CRVO have lower levels of vitamin d than matched controls.

Conditions

Vitamin d Deficiency; Central Retinal Vein Occlusion

Keywords

Vitamin d deficiency; Central retinal vein occlusion

Outcome Measures

Primary Outcomes (1)

• Vitamin D levels

  one year

Study Arms (2)

CRVO patients

Patients with a newly diagnosed CRVO. Maximum duration 3 months.

Control patients

Controls matched for age,gender, month of onset from the Central Bureau of Statistics Sweden

Eligibility Criteria

• Age: 50 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients with central retinal vein occlusion diagnosed at St Eriks Eye Hospital

You may qualify if:

• Newly diagnosed central retinal vein occlusion (3 months)

Sponsors & Collaborators

• St. Erik Eye Hospital: lead

Study Sites (1)

St Eriks Eye Hospital

Stockholm, Stockholm County, 11282, Sweden

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood sample of vitamin D

MeSH Terms

Conditions

Vitamin D Deficiency; Retinal Vein Occlusion

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Retinal Diseases; Eye Diseases; Venous Thrombosis; Thrombosis; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 13, 2013
• First Posted: February 15, 2013
• Study Start: January 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: November 1, 2014
• Last Updated: November 25, 2016

Record last verified: 2016-11

Locations

SE (1)