Effect of Dexmedetomidine on Cisatracurium Infusion and Sufentanil Consumption and Its Variations in Different Age Groups, Using a Closed Loop Computer Controlled System.
Sponsor study identifier
interventional
150
1 country
1
Study Start
November 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2013
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Study Completion
Not reported
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November 2012
Date type not reportedThis date has not been verified as actual or estimated.
February 2013
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
February 4, 2013
Actual (reported)February 7, 2013
Actual (reported)Cisatracurium infusion consumption.
Measurements were done during the operation. Cisatracurium infusion was controlled a closed loop computer system. The degree of neuromuscular blockage was assessed every 20 seconds throughout the procedure using the train of four testing. It was done by counting the number and amplitude of twitches evoked after electrical stimulus and the rate of infusion maintained itself at the low rate of 0.20µg/kg/min as long as the T1 response is less than 1%. When the T1 \> 1%, the rate of infusion would automatically increase to 5.0 µg/kg/min until T1 \< 1%, after which the infusion rate would fall back to 0.20µg/kg/min. The controlled infusion described above administered small doses of cisatracurium intra-operatively to maintain a muscle relaxation of more than 99%. The system saved the time and amount of drug given throughout the operation, from which the consumption was calculated in µg/kg/min.
At the time of surgery
Sufentanil consumption.
At the time of operation.
In this group patients were aged from 20 to 45. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55. Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
In this group patients were aged from 46 to 65. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55. Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
In this intervention we compared the cisatracurium consumption, recovery index and sufentanil consumption between P2 and D. The reason we are comparing patients in group D with P2 is that because they belong to the same age group.
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, 300052, China
Joomye S, Yan D, Wang H, Zhou G, Wang G. Consumption of Cisatracurium in different age groups, using a closed loop computer controlled system. BMC Anesthesiol. 2014 Apr 21;14:29. doi: 10.1186/1471-2253-14-29. eCollection 2014.
Guolin Wang, MD, PhD, Professor
Tianjin Medical University General Hospital
First Submitted
February 4, 2013
First Posted
February 7, 2013
Study Start
November 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2013
Recovery Index
30 minutes post-operative.
In this group patients were aged from 66 to 85. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55. Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
In this group patients were aged from 46to 65. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55. Dexmedetomidine infusion is started at induction,a bolus dose of 0.5 µg/kg is given over the first hour which is followed by infusion of 0.4 µg/kg/hr. Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
For this intervention, we compared the cisatracurium consumption, refractory index and sufentanil consumption between group P1, P2 and P3.
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
February 7, 2013
Record last verified: 2013-02
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