NCT01784835

Brief Summary

The application of osteopathic manipulative treatment (OMT) in preterm infants has been demonstrated to be effective in reducing length of stay (LOS). The scope of the present study is to investigate the association between earlier exposure to OMT and reduction of LOS in premature infants

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
113

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2010

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2010

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2012

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

February 4, 2013

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 6, 2013

Completed
Last Updated

February 6, 2013

Status Verified

February 1, 2013

Enrollment Period

1.8 years

First QC Date

February 4, 2013

Last Update Submit

February 4, 2013

Conditions

Keywords

Osteopathic manipulative treatmentneonatologyneonatal careprematuritycomplementary and alternative medicinelength of stay

Outcome Measures

Primary Outcomes (1)

  • Number of days of LOS

    participants will be followed for the duration of hospital stay, an expected average of 4 weeks

Secondary Outcomes (1)

  • effectiveness of OMT considering different lag time between birth and the first OMT

    participants will be followed for the duration of hospital stay, an expected average of 4 weeks

Study Arms (2)

control

OTHER

patients under standard medical care

Other: Usual care

OMT

EXPERIMENTAL

patients under usual medical care plus osteopathic treatment

Other: osteopathic manipulative treatment

Interventions

Patients from this group received osteopathic treatments twice a week for the entire length of stay in the unit.

OMT

Patients from control group received standard care plus osteopathic evaluation only, according to the same schedule as the study group.

control

Eligibility Criteria

Age32 Weeks - 37 Weeks
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • preterm infants born at age between 29 and 37 weeks
  • osteopathic treatment performed \< 14 days after birth
  • preterms born in the same hospital

You may not qualify if:

  • Gestational age \< 29 weeks
  • Gestational age \> 37 weeks
  • First OMT performed after 14 days from birth
  • genetic disorders
  • congenital disorders
  • cardiovascular abnormalities
  • proven or suspected necrotized enterocolitis with or without gastrointestinal perforation proven or suspected abdominal obstruction
  • pre/post surgery patients
  • pneumoperitoneum
  • atelectasis
  • Newborn from an HIV seropositive/drug addicted mother
  • respiratory disorders
  • transferred to/from other hospital
  • admitted for preterminal comfort care (defined as neither intubation nor cardio-respiratory resuscitation)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Macerata Hospital

Macerata, Macerata, 62100, Italy

Location

Related Publications (1)

  • Pizzolorusso G, Turi P, Barlafante G, Cerritelli F, Renzetti C, Cozzolino V, D'Orazio M, Fusilli P, Carinci F, D'Incecco C. Effect of osteopathic manipulative treatment on gastrointestinal function and length of stay of preterm infants: an exploratory study. Chiropr Man Therap. 2011 Jun 28;19(1):15. doi: 10.1186/2045-709X-19-15.

    PMID: 21711535BACKGROUND

MeSH Terms

Conditions

Premature Birth

Interventions

Manipulation, Osteopathic

Condition Hierarchy (Ancestors)

Obstetric Labor, PrematureObstetric Labor ComplicationsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Intervention Hierarchy (Ancestors)

Musculoskeletal ManipulationsComplementary TherapiesTherapeuticsPhysical Therapy ModalitiesRehabilitation

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 4, 2013

First Posted

February 6, 2013

Study Start

October 1, 2010

Primary Completion

July 1, 2012

Study Completion

July 1, 2012

Last Updated

February 6, 2013

Record last verified: 2013-02

Locations