Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis

NCT01784458 | Completed

• 1 other identifier: 2009-0004
• Study Type: observational
• Target: 46
• Locations: 0 countries
• Sites: N/A

Brief Summary

• Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity
• many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction
• In previous studies, most of them was based on the septic patients of medical diseases. And it is rare about sepsis of surgical diseases such as traumatized or postoperative patients
• We hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality
• Our study was aimed to investigate prevalence of IAH and risk factors and to analyze clinical course and prognosis influenced by IAH in surgical patients with severe sepsis

Conditions

Bowel Perforation; Abscess; Leakage; Peritonitis; Pneumonia

Keywords

severe sepsis; intra-abdominal hypertension; intra-abdominal pressure

Outcome Measures

Primary Outcomes (1)

• effects of intra-abdominal hypertension on clinical course and outcome in surgical patients with severe sepsis

  length of ICU stay length of hospital stay ventilator free days effect on enteral feeding 28 day and 60 day mortality

  within 60 days after admission in surgical intensive care unit

Study Arms (1)

intra-abdominal hypertension(IAH)

IAH group : patients developing IAH non-IAH group : patients without IAH

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients admitted to surgical intensive care unit with severe sepsis

You may qualify if:

• older than 18-year
• agreed on informed consent
• diagnosed with severe sepsis

You may not qualify if:

• traumatic injuries on urethra or bladder
• open abdomen status

Sponsors & Collaborators

• University of Ulsan: lead

Related Publications (6)

• Cheatham ML, Malbrain ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppaniemi A, Olvera C, Ivatury R, D'Amours S, Wendon J, Hillman K, Wilmer A. Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations. Intensive Care Med. 2007 Jun;33(6):951-62. doi: 10.1007/s00134-007-0592-4. Epub 2007 Mar 22.

  PMID: 17377769 BACKGROUND

• Pelosi P, Croci M, Ravagnan I, Cerisara M, Vicardi P, Lissoni A, Gattinoni L. Respiratory system mechanics in sedated, paralyzed, morbidly obese patients. J Appl Physiol (1985). 1997 Mar;82(3):811-8. doi: 10.1152/jappl.1997.82.3.811.

  PMID: 9074968 BACKGROUND

• Hering R, Wrigge H, Vorwerk R, Brensing KA, Schroder S, Zinserling J, Hoeft A, Spiegel TV, Putensen C. The effects of prone positioning on intraabdominal pressure and cardiovascular and renal function in patients with acute lung injury. Anesth Analg. 2001 May;92(5):1226-31. doi: 10.1097/00000539-200105000-00027.

  PMID: 11323351 BACKGROUND

• Malbrain ML, Chiumello D, Pelosi P, Bihari D, Innes R, Ranieri VM, Del Turco M, Wilmer A, Brienza N, Malcangi V, Cohen J, Japiassu A, De Keulenaer BL, Daelemans R, Jacquet L, Laterre PF, Frank G, de Souza P, Cesana B, Gattinoni L. Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study. Crit Care Med. 2005 Feb;33(2):315-22. doi: 10.1097/01.ccm.0000153408.09806.1b.

  PMID: 15699833 BACKGROUND

• Malbrain ML, Cheatham ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppaniemi A, Olvera C, Ivatury R, D'Amours S, Wendon J, Hillman K, Johansson K, Kolkman K, Wilmer A. Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions. Intensive Care Med. 2006 Nov;32(11):1722-32. doi: 10.1007/s00134-006-0349-5. Epub 2006 Sep 12.

  PMID: 16967294 RESULT

• Kyoung KH, Hong SK. The duration of intra-abdominal hypertension strongly predicts outcomes for the critically ill surgical patients: a prospective observational study. World J Emerg Surg. 2015 May 30;10:22. doi: 10.1186/s13017-015-0016-7. eCollection 2015.

  PMID: 26056530 DERIVED

MeSH Terms

Conditions

Intestinal Perforation; Abscess; Peritonitis; Pneumonia; Sepsis; Intra-Abdominal Hypertension

Condition Hierarchy (Ancestors)

Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Suppuration; Infections; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Intraabdominal Infections; Peritoneal Diseases; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Systemic Inflammatory Response Syndrome; Compartment Syndromes; Muscular Diseases; Musculoskeletal Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Suk-Kyung Hong

  Division of Trauma and Surgical Critical Care, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: kyu-Hyouck Kyoung/clinical assistant professor

Study Record Dates

• First Submitted: February 3, 2013
• First Posted: February 5, 2013
• Study Start: March 1, 2009
• Primary Completion: October 1, 2009
• Study Completion: October 1, 2009
• Last Updated: February 5, 2013

Record last verified: 2013-02