Serial Collection of Primary Progressive Multiple Sclerosis Participants in the MURDOCK Study

NCT01776060 | Completed DMC

• 1 other identifier: Pro00040961
• Study Type: observational
• Target: 28
• Locations: 1 country
• Sites: 3

Brief Summary

The goal of this study is to enroll 100 participants with Primary Progressive Multiple Sclerosis (PPMS) that have joined the MURDOCK Study Horizon 1.5 (Duke IRB Pro00011196) and the Multiple Sclerosis cohort (Duke IRB Pro00023791). All 100 participants will complete a biannual collection of a follow up questionnaire and blood/urine collection for a period of 5 years.

Conditions

Primary Progressive Multiple Sclerosis

Keywords

Primary Progressive Multiple Sclerosis; Multiple Sclerosis; biomarker; 'omic; progression

Outcome Measures

Primary Outcomes (1)

• Generation of 'omic markers of disease progression

  Biannual collection of samples from PPMS patients would not only permit the identification of 'omic profiles that can be compared and contrasted to those from RRMS patients in a parallel study, but it would also allow the generation of 'omic markers of disease progression. This progressive etiology would provide valuable insight into PPMS development and may also shed light on SPMS progression.

  5 years

Interventions

generation of 'omic markers of disease progression OTHER

Aside from first in disease sampling, the serial, biannual collection of samples from PPMS patients would not only permit the identification of 'omic profiles that can be compared and contrasted to those from RRMS patients in a parallel study, but it would also allow the generation of 'omic markers of disease progression.

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants must enroll in the MURDOCK Study Horizon 1.5 (Pro00011196) as well as the Multiple Sclerosis cohort (Pro00023791) in order to participate in this biannual collection of a follow up questionnaire and blood/urine collection for participants who have Primary Progressive MS. The biannual collection will continue for 5 years. Those participants with PPMS who are already enrolled in the MURDOCK Study Horizon 1.5 and Multiple Sclerosis cohort will be contacted via phone to assess interest in the PPMS study. New participants with PPMS who enroll into the Horizon 1.5 study and Multiple Sclerosis cohort will be asked during the time of enrollment if they would like to participate in the PPMS study as well.

You may qualify if:

• Enrolled in the MURDOCK Study Horizon 1.5 (Pro00011196)
• Enrolled in the Multiple Sclerosis Cohort (Pro00023791)
• Diagnosed with Primary Progressive Multiple Sclerosis
• At least 18 years of age

You may not qualify if:

• Participants not willing to participate or sign informed consent

Sponsors & Collaborators

• Duke University: lead

Study Sites (3)

NE Neurology

Concord, North Carolina, 28025, United States

Location

The Stedman Center on the Duke Center for Living Campus

Durham, North Carolina, 27705, United States

Location

Raleigh Neurology Associates

Raleigh, North Carolina, 27607, United States

Location

Related Links

• Related Info

Biospecimen

Retention: SAMPLES WITH DNA

Blood (RNA/DNA), serum, plasma, urine

MeSH Terms

Conditions

Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis; Disease Progression

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Simon Gr, PhD

  Duke Medicine Site Based Research Group

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 23, 2013
• First Posted: January 25, 2013
• Study Start: January 1, 2013
• Primary Completion: September 21, 2020
• Study Completion: September 21, 2020
• Last Updated: May 21, 2024

Record last verified: 2024-05

Locations

US (3)