NCT01775007|Completed
A Pilot Study to Test the Safety and Feasibility of a Brillouin Ocular Analyzer
Brillouin I
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Brillouin I
Sponsor study identifier
interventional
31
1 country
2
Study Start
March 2011
Actual (reported)Primary Completion
September 2017
Actual (reported)Study Completion
September 2017
Actual (reported)A Brillouin ocular analyzer uses a low-power near infrared laser light to probe the viscoelastic properties of the cornea and crystalline lens in the eye. The study hypothesis is that the instrument can measure the Brillouin light scattering spectra from the eye safely and effectively from human subjects.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2011
Actual (reported)January 22, 2013
Actual (reported)January 24, 2013
Actual (reported)September 2017
Actual (reported)September 2017
Actual (reported)Number of patients with adverse events
Complete standard eye exam including medical and ocular history with manifest refraction, Amsler grid evaluation (macular test), color vision (Ishihara color plates), Scotopic pupil measurement (Colvard pupillometer), Slit lamp biomicroscopy of anterior segment, intraocular pressure measurement, dilated fundoscopic exam (2.5% phenylephrine and 0.5% tropicamide), and corneal topography (Pentacam).
6 months
Sensitivity and accuracy of Brillouin modulus measurement.
at time of imaging session
Brillouin Ocular Analyser
Measurement of the local viscoelastic properties (Brillouin Shift) of the Anterior Eye Segment.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, 02114, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Scarcelli G, Yun SH. In vivo Brillouin optical microscopy of the human eye. Opt Express. 2012 Apr 9;20(8):9197-202. doi: 10.1364/OE.20.009197.
Seok-Hyun Yun, PhD
Massachusetts General Hospital
31 participants (actual enrollment reported by the registry).
First Submitted
January 22, 2013
First Posted
January 24, 2013
Study Start
March 2011
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
September 2017
Actual (reported)Study Completion
September 2017
Actual (reported)Last Updated
August 2, 2022
Record last verified: 2022-07
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Source: ClinicalTrials.gov.
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