Arterial Stiffness in Chronic Kidney Disease

NCT01770847 | Completed DMC

• 1 other identifier: 12\SS\0088
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.

Conditions

Chronic Kidney Disease

Outcome Measures

Primary Outcomes (1)

• Diurnal variations in arterial stiffness

  The principal objective of this study is to evaluate whether diurnal variations in arterial stiffness are blunted in chronic kidney disease compared to healthy age matched controls

  Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am

Secondary Outcomes (2)

• Diurnal variations in aortic and brachial blood pressure

  Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am

• Relationship between changes in blood pressure and arterial stiffness

  Over one 26 hour period

Study Arms (2)

Healthy controls

Healthy age matched controls

Chronic kidney diease

Chronic kidney disease patients stage 2-4

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Potential patients will be identified from renal clinics at the Royal Infirmary and Western General Hospital. Suitable participants will initially be identified by a member of the direct healthcare team. Healthy volunteers will be indentified through the Clinical Research Centre community database and poster advertising at the University of Edinburgh.

You may qualify if:

• Systolic blood pressure \<160 whether or not on antihypertensive medication
• diastolic blood pressure \<100mmHg whether or not on antihypertensive medication
• Chronic kidney disease stage 2-5

You may not qualify if:

• Systolic blood pressure ≥160mmHg
• Diastolic blood pressure ≥100mmhg
• Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)

Sponsors & Collaborators

• University of Edinburgh: lead

Study Sites (1)

Clinical Research Centre, 2nd Floor Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Location

Related Publications (1)

• Dhaun N, Moorhouse R, MacIntyre IM, Melville V, Oosthuyzen W, Kimmitt RA, Brown KE, Kennedy ED, Goddard J, Webb DJ. Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: the role of endothelin-1. Hypertension. 2014 Aug;64(2):296-304. doi: 10.1161/HYPERTENSIONAHA.114.03533.

  PMID: 24890823 DERIVED

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• David J Webb, MB BS MD DSc FRCP FRSE FMedSci

  University of Edinburgh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 28, 2012
• First Posted: January 18, 2013
• Study Start: November 1, 2012
• Primary Completion: December 1, 2013
• Last Updated: November 17, 2017

Record last verified: 2017-11

Locations

GB (1)