Comparison of Efficacy of Ivabradine Versus Metoprolol
IMAGE
Comparison of Efficacy and Safety of Ivabradine Versus Metoprolol for Controlling Heart Rate Prior to 640-Slice Computed Tomographic Angiography in Elective Patients
1 other identifier
interventional
60
1 country
1
Brief Summary
Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4 coronary-artery-disease
Started Dec 2014
Shorter than P25 for phase_4 coronary-artery-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 19, 2012
CompletedFirst Posted
Study publicly available on registry
December 24, 2012
CompletedStudy Start
First participant enrolled
December 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2015
CompletedOctober 29, 2014
October 1, 2014
Same day
December 19, 2012
October 27, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Heart rate of patient before CT coronary
1 January 2013 to 31 december 2013
Secondary Outcomes (1)
safety and side effect of Metoprolol and Ivabradine
1 january 2013 to 31 december 2013
Other Outcomes (1)
Image quality
1 january 2013 to 31 december 2013
Study Arms (2)
Ivabradine
EXPERIMENTALPatients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol
metoprolol
ACTIVE COMPARATORMetoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine
Interventions
Eligibility Criteria
You may qualify if:
- elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital
- Resting heart rate \> 70 BPM
- age \> 18 years and informed consent
You may not qualify if:
- Heart rate \> 100 BPM
- BP \<100/60 mmHg
- recent congestive heart failure in 1 mo.
- SA node, AV node disease and AF
- on permanent pacemaker
- CrCL \< 15ml/min. , AST or ALT \> 3x UNL
- on HR reducing drug such as diltiazem, verapamil, digitalis
- contraindication for ivabradine or metoprolol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Phramonkutklao Hospital
Bangkok, 10400, Thailand
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Purich - Surunchupakorn, M.D.
Phramongkutklao College of Medicine and Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, CARE PROVIDER
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Col. Suthee Panichkul
Study Record Dates
First Submitted
December 19, 2012
First Posted
December 24, 2012
Study Start
December 1, 2014
Primary Completion
December 1, 2014
Study Completion
December 1, 2015
Last Updated
October 29, 2014
Record last verified: 2014-10