Short-term Cognitive Training in Late-life Depression

NCT01748032 | Terminated

• 1 other identifier: 12-28
• Study Type: interventional
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD). The hypotheses are:

1. 1.post-training cognitive performance will be superior to pre-training cognitive performance
2. 2.post-training depressive symptomatology will be less severe as compared with pre-training clinical severity and
3. 3.AUT group will show better post-training cognitive performance and improved mood symptoms when compared with the WAT group.

Conditions

Depression

Keywords

depression; intervention studies

Outcome Measures

Primary Outcomes (1)

• Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed

  Computerized Executive Tasks: * Number-Letter Task * Letter-Memory Task * Stroop Task Non-Computerized Measures: * Cattell Culture Fair Intelligence Test * Mattis Dementia Rating Scale-2 (DRS-2)

  Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day

Secondary Outcomes (1)

• Changes in mood including depression, anxiety and apathy

  Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day

Study Arms (2)

Alternative Uses Training

OTHER

In this task, subjects are asked to produce atypical and alternative uses for common daily objects.

Behavioral: Cognitive training

Word Association Training

OTHER

In this task, subjects are asked to generate the first word that comes to their mind, and thus, encourages more general and spontaneous divergent thinking.

Behavioral: Cognitive training

Interventions

Cognitive training BEHAVIORAL

20 minutes/day for 5 sequential working days

Also known as: cognitive intervention

Alternative Uses Training; Word Association Training

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female
• Age \>=55
• Proficiency in English
• Current depressive episode and meet criteria for DSM-IV major depressive disorder
• Hamilton Depression Rating Scale score \>=15
• Able to give informed consent
• Stable medication dosages during the training period

You may not qualify if:

• Other DSM-IV Axis I psychiatric disorders, except for anxiety disorders due to high comorbidity with mood disorders
• Mini-Mental State Examination score of \<26
• Diagnosis of dementia
• Neurological and medical conditions known to affect cognition (e.g., stroke, head injury, previous chemotherapy for cancer)
• Unstable medical illnesses requiring active treatment
• Vision or hearing impairment affecting ability to participate in training

Sponsors & Collaborators

• Rotman Research Institute at Baycrest: lead
• Baycrest: collaborator

Study Sites (1)

Rotman Research Institute at Baycrest

Toronto, Ontario, M6A 2E1, Canada

Location

MeSH Terms

Conditions

Depression

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Linda Mah, MD, M.H.Sc.

  Rotman Research Institute at Baycrest

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinician Scientist

Study Record Dates

• First Submitted: December 10, 2012
• First Posted: December 12, 2012
• Study Start: August 1, 2012
• Primary Completion: June 1, 2014
• Study Completion: September 1, 2014
• Last Updated: April 7, 2016

Record last verified: 2016-04

Locations

CA (1)