Effects of Transcranial Magnetic Stimulation on Object Recognition

NCT01747200 | Completed

• 2 other identifiers: 13003513-N-0035
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- The brain has natural rhythms called brain waves. An electroencephalogram (EEG) can record these rhythms. When people identify the picture of a familiar object shown on a computer screen, the communication between certain regions of the brain increases. An EEG can detect these communication brain waves. Transcranial magnetic stimulation (TMS) can affect these brain waves by slightly changing the brain s rhythms. Researchers want to see if changing brain rhythms with TMS interferes with the ability to identify pictures of familiar objects. This study will provide more information about how TMS can affect brain waves and behavior. Objectives: \- To see if TMS can interfere with the brain s ability to identify pictures of familiar objects. Eligibility: \- Healthy volunteers between 18 and 70 years of age. Design:

• This study requires two visits to the clinical center. The first visit will last about 2 hours. The second visit will last about 4 hours.
• Participants will be screened with a physical exam and medical history.
• At the first visit, participants will have an object recognition test. Participants will look at pictures of several objects on a computer screen. They will then have to state whether the objects they see on the screen are familiar. The object recognition test will be done along with TMS.
• At the second visit, participants will have an EEG while taking the object recognition test. Brain waves will be monitored during the test. They will then repeat the test while having repetitive TMS to study its effect on object recognition. The participants will then take the object recognition test alone for a final time. This will make sure that TMS effects (if any) on the ability to identify familiar object images are no longer present.

Conditions

Repetitive TMS (rTMS); Sham rTMS; Bilateral rTMS; Unilateral rTMS

Keywords

Repetitive TMS (rTMS)

Outcome Measures

Primary Outcomes (1)

• Percentage of correct responses in the midline object recognition task.

  4 hours

Secondary Outcomes (1)

• Threshold intensity for blocking object recognition

  4 hours

Interventions

Sham rTMS PROCEDURE

Bilateral rTMS at same frequency and in phase PROCEDURE

Bilateral rTMS at different frequencies PROCEDURE

Bilateral rTMSat same frequency and out of phase PROCEDURE

rTMS over TP8 PROCEDURE

rTMS over TP7 PROCEDURE

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 - 70 years.
• Able to give his/her own consent to participate in the study.

You may not qualify if:

• Presence of cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, metal fragments in the eye.
• Pregnancy or lactation.
• History of any serious medical illness or hearing problems
• Intake of medication that affect the central nervous system like anti depressants, antihistamines, antipsychotics, dopamine agonists, benzodiazepines and antiepileptics in the past 3 months.
• Presence of neurological or psychiatric illnesses like brain tumor, migraine, depression, bipolar disorder, schizophrenia.
• History of any seizure.
• Use or abuse of any drug in the past 6 months or intake of more than 7 alcoholic drinks a week in females and more than 14 alcoholic drinks a week in males.
• Presence of metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear implants, artificial heart valves or metal fragments in the eye as these make having an MRI unsafe.
• Presence of metallic dental fillings which are likely to cause MRI artifacts
• Uncomfortable being in a small space for up to 2 hours.
• Unable to lie flat on the back for up to 2 hours

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Adler G, Brassen S, Jajcevic A. EEG coherence in Alzheimer's dementia. J Neural Transm (Vienna). 2003 Sep;110(9):1051-8. doi: 10.1007/s00702-003-0024-8.

  PMID: 12928837 BACKGROUND

• Gerloff C, Andres FG. Bimanual coordination and interhemispheric interaction. Acta Psychol (Amst). 2002 Jun;110(2-3):161-86. doi: 10.1016/s0001-6918(02)00032-x.

  PMID: 12102104 BACKGROUND

• Gray CM, Singer W. Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1698-702. doi: 10.1073/pnas.86.5.1698.

  PMID: 2922407 BACKGROUND

Study Officials

• Mark Hallett, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 8, 2012
• First Posted: December 11, 2012
• Study Start: November 16, 2012
• Primary Completion: January 26, 2017
• Study Completion: January 26, 2017
• Last Updated: July 2, 2017

Record last verified: 2017-01-26

Locations

US (1)