Dexamethasone Added to Levobupivacaine Improves Postoperative Analgesia

NCT01739270 | Unknown

• 1 other identifier: 0911
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Adding dexamethasone to local anesthetic will significantly prolong duration of brachial plexus anesthesia and analgesia.

Conditions

Brachial Plexus Anesthesia; Analgesia

Keywords

analgesia; regional anesthesia; surgery; duration of analgesia; dexamethasone added to levobupivacaine compared to levobupivacaine alone

Outcome Measures

Primary Outcomes (1)

• duration of analgesia

  Duration of analgesia after supraclavicular block

  24 hour postoperatively

Secondary Outcomes (1)

• postoperative analgesic consumption

  24 hour

Study Arms (2)

dexamethasone with levobupivacaine

ACTIVE COMPARATOR

25ml 0.5% levobupivacaine plus 4mg Dexamethasone are given for supraclavicular brachial plexus block for upper extremity surgery

Procedure: supraclavicular brachial plexus block

levobupivacaine

ACTIVE COMPARATOR

25ml 0.5% levobupivacaine plus 1ml 0.9% saline are given for supraclavicular brachial plexus block for upper extremity surgery

Procedure: supraclavicular brachial plexus block

Interventions

supraclavicular brachial plexus block PROCEDURE

dexamethasone with levobupivacaine; levobupivacaine

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients aged 18 years or older
• ASA (American Society of Anesthesiologists) physical status I, II or III

You may not qualify if:

• refusal of the patients to give informed consent
• preexisting coagulation disorders
• local infection at the site of the block
• neuropathy
• drug or alcohol abusers
• known allergy to the drug used in study
• operation time exceeding six hours

Sponsors & Collaborators

• University Hospital Dubrava: lead

Study Sites (1)

Clinical Hospital Dubrava

Zagreb, 10000, Croatia

Location

Related Publications (3)

• Parrington SJ, O'Donnell D, Chan VW, Brown-Shreves D, Subramanyam R, Qu M, Brull R. Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):422-6. doi: 10.1097/AAP.0b013e3181e85eb9.

  PMID: 20814282 RESULT

• Vieira PA, Pulai I, Tsao GC, Manikantan P, Keller B, Connelly NR. Dexamethasone with bupivacaine increases duration of analgesia in ultrasound-guided interscalene brachial plexus blockade. Eur J Anaesthesiol. 2010 Mar;27(3):285-8. doi: 10.1097/EJA.0b013e3283350c38.

  PMID: 20009936 RESULT

• Kim YJ, Lee GY, Kim DY, Kim CH, Baik HJ, Heo S. Dexamathasone added to levobupivacaine improves postoperative analgesia in ultrasound guided interscalene brachial plexus blockade for arthroscopic shoulder surgery. Korean J Anesthesiol. 2012 Feb;62(2):130-4. doi: 10.4097/kjae.2012.62.2.130. Epub 2012 Feb 20.

  PMID: 22379567 RESULT

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Ino Husedzinovic, Professor

  Clinical Hospital Dubrava, Head of Anesthesiology, Resuscitation and Intensive Care Medicine

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology, Resuscitation and Intensive Care Medicine Specialist

Study Record Dates

• First Submitted: November 25, 2012
• First Posted: December 3, 2012
• Study Start: October 1, 2012
• Primary Completion: January 1, 2013
• Last Updated: July 29, 2015

Record last verified: 2015-07

Locations

CR (1)