NCT01738568

Brief Summary

Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
27

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2012

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2012

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

November 27, 2012

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 30, 2012

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 12, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 12, 2015

Completed
Last Updated

August 30, 2021

Status Verified

August 1, 2021

Enrollment Period

2.4 years

First QC Date

November 27, 2012

Last Update Submit

August 24, 2021

Conditions

Dementia

Keywords

High intensity aerobic training

Outcome Measures

Primary Outcomes (1)

  • Change in Brain Glucose Uptake

    The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.

    12 weeks

Study Arms (1)

Exercise

EXPERIMENTAL

Aerobic exercise

Behavioral: High intensity aerobic trainingBehavioral: Sedentary Control

Interventions

High intensity aerobic trainingBEHAVIORAL

High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at \~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.

Exercise
Sedentary ControlBEHAVIORAL

Sedentary control participants will not perform any regular exercise for 12-weeks.

Exercise

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 18-30 years or 65-80 years

You may not qualify if:

  • Body mass index (BMI) \>31 kg/m2
  • Smoking
  • Pregnancy
  • Participation in structured exercise (\>2 times per week for 30 minutes or longer)
  • Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
  • Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
  • Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
  • Claustrophobia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Related Publications (1)

  • Robinson MM, Lowe VJ, Nair KS. Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults. J Clin Endocrinol Metab. 2018 Jan 1;103(1):221-227. doi: 10.1210/jc.2017-01571.

    PMID: 29077855DERIVED

Related Links

MeSH Terms

Conditions

Dementia

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental Disorders

Study Officials

  • Val Lowe, MD

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PI

Study Record Dates

First Submitted

November 27, 2012

First Posted

November 30, 2012

Study Start

October 1, 2012

Primary Completion

February 12, 2015

Study Completion

February 12, 2015

Last Updated

August 30, 2021

Record last verified: 2021-08

Locations

US(1)